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231223s2011 xx |||||o 00| ||eng c |
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|a 10.1021/la104270b
|2 doi
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|a DE-627
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|a eng
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|a Haque, Al-Monsur Jiaul
|e verfasserin
|4 aut
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|a Aldehyde-functionalized benzenediazonium cation for multiprobe immobilization on microelectrode array surfaces
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|c 2011
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|a Text
|b txt
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 02.05.2011
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|a Date Revised 25.01.2011
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a We report in situ generation of aldehyde-functionalized benzenediazonium cation (ABD) and its use as a suitable linker molecule for fast and selective immobilization of biomolecules on indium-tin-oxide (ITO) electrode surfaces. We prepared ABD through a new reaction procedure, a simultaneous diazotation of the amine group and deprotection of the aldehyde group from an aniline derivative, 2-(4-aminophenyl)-1,3-dithiane, which was revealed on the ITO electrode surfaces through the electrodeposition of the reaction product and the characterization of the resulting surfaces with cyclic voltammetry, X-ray photoelectron spectroscopy, and protein immobilization. We also showed that successive electrodeposition of ABD and probe molecules on individually addressable microarray electrode surfaces can provide a useful platform for efficient detection of multianalyte. The usage of ABD has been demonstrated by the patterning of three different probe molecules on a single substrate and the simultaneous detection of two target molecules
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Aldehydes
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|a Cations
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|a Diazonium Compounds
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|a Tin Compounds
|2 NLM
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|a benzenediazonium
|2 NLM
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|a 2684-02-8
|2 NLM
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|a indium tin oxide
|2 NLM
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|a 71243-84-0
|2 NLM
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|a Kim, Kyuwon
|e verfasserin
|4 aut
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 27(2011), 3 vom: 01. Feb., Seite 882-6
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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|g volume:27
|g year:2011
|g number:3
|g day:01
|g month:02
|g pages:882-6
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|u http://dx.doi.org/10.1021/la104270b
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