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231223s2010 xx |||||o 00| ||eng c |
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|a 10.1109/TUFFC.2010.1741
|2 doi
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|a eng
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| 100 |
1 |
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|a Lai, Chun-Yen
|e verfasserin
|4 aut
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| 245 |
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|a Noninvasive thermometry assisted by a dual-function ultrasound transducer for mild hyperthermia
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|c 2010
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|a Text
|b txt
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 29.03.2011
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|a Date Revised 29.05.2025
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|a published: Print
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|a Citation Status MEDLINE
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|a Mild hyperthermia is increasingly important for the activation of temperature-sensitive drug delivery vehicles. Noninvasive ultrasound thermometry based on a 2-D speckle tracking algorithm was examined in this study. Here, a commercial ultrasound scanner, a customized co-linear array transducer, and a controlling PC system were used to generate mild hyperthermia. Because the co-linear array transducer is capable of both therapy and imaging at widely separated frequencies, RF image frames were acquired during therapeutic insonation and then exported for off-line analysis. For in vivo studies in a mouse model, before temperature estimation, motion correction was applied between a reference RF frame and subsequent RF frames. Both in vitro and in vivo experiments were examined; in the in vitro and in vivo studies, the average temperature error had a standard deviation of 0.7°C and 0.8°C, respectively. The application of motion correction improved the accuracy of temperature estimation, where the error range was 1.9 to 4.5°C without correction compared with 1.1 to 1.0°C following correction. This study demonstrates the feasibility of combining therapy and monitoring using a commercial system. In the future, real-time temperature estimation will be incorporated into this system
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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| 650 |
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|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Sepharose
|2 NLM
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|a 9012-36-6
|2 NLM
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| 700 |
1 |
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|a Kruse, Dustin E
|e verfasserin
|4 aut
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1 |
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|a Caskey, Charles F
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Stephens, Douglas N
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sutcliffe, Patrick L
|e verfasserin
|4 aut
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| 700 |
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|a Ferrara, Katherine W
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t IEEE transactions on ultrasonics, ferroelectrics, and frequency control
|d 1986
|g 57(2010), 12 vom: 01. Dez., Seite 2671-84
|w (DE-627)NLM098181017
|x 1525-8955
|7 nnas
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| 773 |
1 |
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|g volume:57
|g year:2010
|g number:12
|g day:01
|g month:12
|g pages:2671-84
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|u http://dx.doi.org/10.1109/TUFFC.2010.1741
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