An efficient and information-rich biochemical method design for fragment library screening on ion channels
Drug discovery requires a simple, rapid, and cost-effective method for the early identification of novel leads and elimination of poor candidates. Here we present an experimental design that fulfils these criteria, using a ligand-gated ion channel expressed in a mammalian cell line, whose function c...
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Bibliographische Detailangaben
| Veröffentlicht in: | BioTechniques. - 1988. - 49(2010), 5 vom: 15. Nov., Seite 822-9
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| 1. Verfasser: |
Thompson, Andrew J
(VerfasserIn) |
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| Weitere Verfasser: |
Verheij, Mark H P,
Leurs, Rob,
De Esch, Iwan J P,
Lummis, Sarah C R |
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| Format: | Online-Aufsatz
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| Sprache: | English |
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| Veröffentlicht: |
2010
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| Zugriff auf das übergeordnete Werk: | BioTechniques
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| Schlagworte: | Journal Article
Research Support, Non-U.S. Gov't
Fluorescent Dyes
Ligand-Gated Ion Channels
Receptors, Serotonin, 5-HT3
Serotonin Antagonists
Tritium
10028-17-8
Serotonin
333DO1RDJY
mehr...
Granisetron
WZG3J2MCOL |
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