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231223s2011 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2010.10.003
|2 doi
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|a pubmed24n0679.xml
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Lundell, Anna-Carin
|e verfasserin
|4 aut
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|a Development of gut-homing receptors on circulating B cells during infancy
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|c 2011
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 08.03.2011
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|a Date Revised 16.11.2017
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2010 Elsevier Inc. All rights reserved.
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|a B cell gut-homing is mainly mediated by α4β7, CCR9 and CCR10. We here studied the expression of these receptors on B cells from cord blood and from peripheral blood at 1, 4, 18 and 36 months of age in a prospective cohort of Swedish infants. The proportion of all B cells expressing α4β7 as well as the fraction of CCR10+ B cells expressing α4β7 was highest in early infancy. Nearly all naïve B cells in all age groups expressed α4β7, whereas the expression on class-switched B cells decreased with age. Moreover, the proportion of both IgA+ and IgG+ B cells expressing α4β7, CCR9 and CCR10 were higher during the first months when compared to adults. In conclusion, the high fraction of circulating IgA+ and IgG+ B cells expressing CCR9 and CCR10 in the first months of life indicates activation of naïve B cells in the gut, coinciding with bacterial colonization
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a CC chemokine receptor 9
|2 NLM
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| 650 |
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|a CCR10 protein, human
|2 NLM
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| 650 |
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|a Immunoglobulin A
|2 NLM
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|a Immunoglobulin G
|2 NLM
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|a Integrins
|2 NLM
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|a Receptors, CCR
|2 NLM
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|a Receptors, CCR10
|2 NLM
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| 650 |
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|a Receptors, Lymphocyte Homing
|2 NLM
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|a Tumor Necrosis Factor Receptor Superfamily, Member 7
|2 NLM
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| 650 |
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|a integrin alpha4beta7
|2 NLM
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| 700 |
1 |
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|a Rabe, Hardis
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Quiding-Järbrink, Marianne
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Andersson, Kerstin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Nordström, Inger
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Adlerberth, Ingegerd
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wold, Agnes E
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rudin, Anna
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 138(2011), 1 vom: 15. Jan., Seite 97-106
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:138
|g year:2011
|g number:1
|g day:15
|g month:01
|g pages:97-106
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|u http://dx.doi.org/10.1016/j.clim.2010.10.003
|3 Volltext
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