Reversion of resistance to immunosuppressive agents in three patients with psoriatic arthritis by cyclosporine A modulation of P-glycoprotein function

Reversion of resistance to immunosuppressive agents in three patients with psoriatic arthritis by cyclosporine A : modulation of P-glycoprotein function

Copyright © 2010 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 138(2011), 1 vom: 13. Jan., Seite 9-13
1. Verfasser: Diamanti, Andrea Picchianti (VerfasserIn)
Weitere Verfasser: Rosado, Manuela, Germano, Valentina, Scarsella, Marco, Giorda, Ezio, Podestà, Edoardo, D'Amelio, Raffaele, Carsetti, Rita, Laganà, Bruno
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2011
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Case Reports Journal Article ATP Binding Cassette Transporter, Subfamily B, Member 1 CD3 Complex Immunosuppressive Agents Rhodamine 123 1N3CZ14C5O Sulfasalazine 3XC8GUZ6CB Cyclosporine mehr... 83HN0GTJ6D C-Reactive Protein 9007-41-4 Verapamil CJ0O37KU29 Methotrexate YL5FZ2Y5U1
Beschreibung
Zusammenfassung:Copyright © 2010 Elsevier Inc. All rights reserved.
Secondary resistance may be a major problem in the management of autoimmune diseases. P-glycoprotein (P-gp) over-function has been described as a mechanism of drug resistance in autoimmune patients. P-gp function can in vitro be inhibited by cyclosporine A (CSA) and verapamil; moreover, P-gp reduction by CSA in systemic lupus erythematosus and rheumatoid arthritis has been demonstrated. Here, P-gp function before and after CSA administration in three psoriatic arthritis (PsA) patients, who developed a resistance to MTX/SSA, has been evaluated. P-gp function on patient cells was analyzed by measuring the changes in rhodamine-123 (Rh-123) fluorescence after verapamil incubation. CSA treatment resulted in good clinical outcome that was related with a significant P-gp function reduction at CD3+ and CD8+ levels. In addition to its immunosuppressive activity, CSA results may also be related to MTX/SSA effect restoration through P-gp inhibition. This is the first time that CSA has been demonstrated as being able to revert MTX/SSA resistance in PsA
Beschreibung:Date Completed 08.03.2011
Date Revised 17.03.2022
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2010.10.001