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231223s2010 xx |||||o 00| ||eng c |
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|a 10.1021/la103738e
|2 doi
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|a pubmed24n0678.xml
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Jiang, Wei
|e verfasserin
|4 aut
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| 245 |
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|a Interaction between oxide nanoparticles and biomolecules of the bacterial cell envelope as examined by infrared spectroscopy
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|c 2010
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 06.04.2011
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|a Date Revised 21.11.2013
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a The effects of Al(2)O(3), TiO(2), and ZnO nanoparticles (NPs) on bacteria cells and bacterial surface biomolecules were studied by Fourier transform infrared (FTIR) spectroscopy. All the examined biomolecules showed IR spectral changes after NP exposure. Lipopolysaccharide and lipoteichoic acid could bind to oxide NPs through hydrogen bonding and ligand exchange, but the cytotoxicity of NPs seemed largely related to the function-involved or devastating changes to proteins and phospholipids of bacteria. The three NPs decreased the intensity ratio of β-sheets/α-helices, indicating protein structure change, which may affect cell physiological activities. The phosphodiester bond of L-α-phosphatidylethanolamine was broken by ZnO NPs, forming phosphate monoesters and resulting in the highly disordered alkyl chain. Such damage to phospholipid molecular structure may lead to membrane rupture and cell leaking, which is consistent with the fact that ZnO is the most toxic of the three NPs. The cell surface biomolecular changes revealed by FTIR spectra provide a better understanding of the cytotoxicity of oxide NPs
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Research Support, U.S. Gov't, Non-P.H.S.
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|a Oxides
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|a Zinc Oxide
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|a SOI2LOH54Z
|2 NLM
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|a Yang, Kun
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|4 aut
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|a Vachet, Richard W
|e verfasserin
|4 aut
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|a Xing, Baoshan
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 26(2010), 23 vom: 07. Dez., Seite 18071-7
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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|g volume:26
|g year:2010
|g number:23
|g day:07
|g month:12
|g pages:18071-7
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|u http://dx.doi.org/10.1021/la103738e
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