Synovial fluid-derived T helper 17 cells correlate with inflammatory activity in arthritis, irrespectively of diagnosis

Copyright © 2010 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 138(2011), 1 vom: 24. Jan., Seite 107-16
1. Verfasser: Zizzo, Gaetano (VerfasserIn)
Weitere Verfasser: De Santis, Maria, Bosello, Silvia Laura, Fedele, Anna Laura, Peluso, Giusy, Gremese, Elisa, Tolusso, Barbara, Ferraccioli, GianFranco
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2011
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Receptors, Antigen, T-Cell antigen T cell receptor, zeta chain Interferon-gamma 82115-62-6 Fibrinogen 9001-32-5 C-Reactive Protein 9007-41-4 ZAP-70 Protein-Tyrosine Kinase EC 2.7.10.2
Beschreibung
Zusammenfassung:Copyright © 2010 Elsevier Inc. All rights reserved.
We analyzed peripheral blood (PB) and synovial fluid (SF) mononuclear cells from 16 rheumatoid arthritis (RA), 9 spondyloarthritis (SpA), 3 microcrystal arthritis patients, to define the presence of Th17 and Th1 and their relationship with inflammatory activity, and TCR-zeta chain and ZAP-70 levels. Th17 were significantly higher in SF than in PB and more abundant in microcrystal arthritis patients compared to the other groups. Irrespectively of the diagnosis, SF Th17 percentages correlated with joint (SF total leukocyte count, neutrophil percentage) and systemic (C reactive protein [CRP], fibrinogen, erythrocyte sedimentation rate) inflammation markers. SF Th1 percentages directly correlated with inflammation and disease activity (CRP, swollen joint count [SJC]) indices in SpA, but not in RA patients. These observations support the role of Th17 in the pathogenesis of inflammatory arthritides. The TCR-zeta(dim) lymphocytes in SF were found to produce the highest amounts of cytokines including IL-17, whereas no ZAP-70 impairment was associated to Th17
Beschreibung:Date Completed 08.03.2011
Date Revised 21.03.2022
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2010.10.002