Complexation between α-cyclodextrin and PEGylated-PAMAM dendrimers at low and high pH values
Poly(ethylene glycol)-grafted-poly(amido amine) (PEGylated-PAMAM) dendrimers have attracted increasing amounts of attention because of their improved stability, toxicity, and better particle drug leakage property. The complexation of α-cyclodextrin (α-CD) with grafted PEG segments on the surface of...
| Veröffentlicht in: | Langmuir : the ACS journal of surfaces and colloids. - 1992. - 26(2010), 23 vom: 07. Dez., Seite 17969-74 |
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| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2010
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| Zugriff auf das übergeordnete Werk: | Langmuir : the ACS journal of surfaces and colloids |
| Schlagworte: | Journal Article Amines Dendrimers PAMAM Starburst alpha-Cyclodextrins Polyethylene Glycols 3WJQ0SDW1A alpha-cyclodextrin Z1LH97KTRM |
| Zusammenfassung: | Poly(ethylene glycol)-grafted-poly(amido amine) (PEGylated-PAMAM) dendrimers have attracted increasing amounts of attention because of their improved stability, toxicity, and better particle drug leakage property. The complexation of α-cyclodextrin (α-CD) with grafted PEG segments on the surface of PAMAM dendrimers was elucidated by light scattering and titration calorimetry. At pH 10, complexation between α-CD and PEGylated-PAMAM occurred once α-CD was titrated into the PAMAM solution. We observed for the first time a unique phenomenon at pH 2, where no binding took place until a critical α-CD concentration (C*) of ∼8.0 mM was reached. The size of the nanostructures increased from 6.7 to 57.6 nm when the α-CD concentration was increased from 0.5 to 15 mM at pH 2. The zeta potential of PEGylated-PAMAM at pH 2 was +6.7 mV. Thus, the dendrimers possessed positive charges attributed to the protonation of primary amine groups on PAMAM chains that impart electrostatic repulsive forces to the system. The morphology of the complex is expected to be different at two different pH values (2 and 10) because the former produces a clear solution and the latter forms a turbid solution with white precipitates |
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| Beschreibung: | Date Completed 06.04.2011 Date Revised 01.12.2018 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1520-5827 |
| DOI: | 10.1021/la103287r |