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231223s2010 xx |||||o 00| ||eng c |
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|a 10.1021/la103109b
|2 doi
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|a pubmed24n0675.xml
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|a (DE-627)NLM202543293
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|a (NLM)20964349
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Reum, Nico
|e verfasserin
|4 aut
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1 |
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|a Multilayer coating of gold nanoparticles with drug-polymer coadsorbates
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|c 2010
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 04.03.2011
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|a Date Revised 19.11.2015
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a The aim of our present study was the development of a drug multilayer-based carrier system for delivery of water-insoluble drugs. As drug, we applied the anticancer drug 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin, mTHPP, which is a model photosensitizer for photodynamic therapy. Gold nanoparticles (AuNP) with a diameter of 14.5 ± 0.9 nm were prepared and used as template for the layer-by-layer approach. The drug and the negatively charged polyelectrolyte (PE) poly(styrene sulfonate) sodium salt (PSS) were complexed with a new developed method using freeze-drying. The complexation efficiency was determined to be ∼11-12 monomers PSS per mTHPP molecule by CHNS analysis and UV/vis measurement. Molecular docking simulations revealed π-π interactions and H-bonding to be the responsible mechanisms. A drug multilayer system based on the layer-by-layer (LbL) technique utilized the water-soluble complex as anionic layer material and poly(allylamine hydrochloride) (PAH) as cationic layer. The modified AuNP were characterized by different physicochemical techniques such as UV/vis, ζ-potential, ICP-OES, and TEM. To the best of our knowledge, we could demonstrate for the first time the adsorption of three drug layers to a nanoparticulate system. Furthermore, the adaptation of the LbL-technique resulted in drastically increased drug deposition efficiency (factor of 100). Furthermore, we developed a new and comfortable way to solubilize water-insoluble drugs in water
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Antineoplastic Agents
|2 NLM
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|a Drug Carriers
|2 NLM
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|a Polyamines
|2 NLM
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|a Polystyrenes
|2 NLM
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|a Porphyrins
|2 NLM
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|a tetra(3-hydroxyphenyl)porphine
|2 NLM
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|a polyallylamine
|2 NLM
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|a 30551-89-4
|2 NLM
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|a polystyrene sulfonic acid
|2 NLM
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|a 70KO0R01RY
|2 NLM
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|a Gold
|2 NLM
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|a 7440-57-5
|2 NLM
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| 700 |
1 |
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|a Fink-Straube, Claudia
|e verfasserin
|4 aut
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1 |
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|a Klein, Tobias
|e verfasserin
|4 aut
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|a Hartmann, Rolf W
|e verfasserin
|4 aut
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|a Lehr, Claus-Michael
|e verfasserin
|4 aut
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|a Schneider, Marc
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 26(2010), 22 vom: 16. Nov., Seite 16901-8
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:26
|g year:2010
|g number:22
|g day:16
|g month:11
|g pages:16901-8
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|u http://dx.doi.org/10.1021/la103109b
|3 Volltext
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