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231223s2011 xx |||||o 00| ||eng c |
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|a 10.1093/jxb/erq316
|2 doi
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|a pubmed24n0675.xml
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|a (NLM)20959624
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|a eng
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|a Destro, Tiziana
|e verfasserin
|4 aut
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|a Compensatory expression and substrate inducibility of gamma-glutamyl transferase GGT2 isoform in Arabidopsis thaliana
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|c 2011
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 11.04.2011
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|a Date Revised 20.10.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a γ-Glutamyl transferases (GGT; EC 2.3.2.2) are glutathione-degrading enzymes that are represented in Arabidopsis thaliana by a small gene family of four members. Two isoforms, GGT1 and GGT2, are apoplastic, sharing broad similarities in their amino acid sequences, but they are differently expressed in the tissues: GGT1 is expressed in roots, leaves, and siliques, while GGT2 was thought to be expressed only in siliques. It is demonstrated here that GGT2 is also expressed in wild-type roots, albeit in very small amounts. GGT2 expression is enhanced in ggt1 knockout mutants, suggesting a compensatory effect to restore GGT activity in the root apoplast. Supplementation with 100 μM glutathione (GSH) resulted in the up-regulation of GGT2 gene expression in wild-type and ggt1 knockout roots, and of GGT1 gene expression in wild-type roots. Glutathione recovery was hampered by the GGT inhibitor serine/borate, suggesting a major role for apoplastic GGTs in this process. These findings can explain the ability of ggt1 knockout mutants to retrieve exogenously added glutathione from the growth medium
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a gamma-Glutamyltransferase
|2 NLM
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| 650 |
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|a EC 2.3.2.2
|2 NLM
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| 650 |
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|a Glutathione
|2 NLM
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|a GAN16C9B8O
|2 NLM
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| 700 |
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|a Prasad, Dinesh
|e verfasserin
|4 aut
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|a Martignago, Damiano
|e verfasserin
|4 aut
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|a Bernet, Ignacio Lliso
|e verfasserin
|4 aut
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|a Trentin, Anna Rita
|e verfasserin
|4 aut
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|a Renu, Indu Kumari
|e verfasserin
|4 aut
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|a Ferretti, Massimo
|e verfasserin
|4 aut
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|a Masi, Antonio
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Journal of experimental botany
|d 1985
|g 62(2011), 2 vom: 13. Jan., Seite 805-14
|w (DE-627)NLM098182706
|x 1460-2431
|7 nnns
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| 773 |
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|g volume:62
|g year:2011
|g number:2
|g day:13
|g month:01
|g pages:805-14
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|u http://dx.doi.org/10.1093/jxb/erq316
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