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231223s2011 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2010.08.003
|2 doi
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|a pubmed25n0675.xml
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|a (NLM)20956091
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|a DE-627
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|c DE-627
|e rakwb
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|a eng
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| 100 |
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|a Yu, Joyce E
|e verfasserin
|4 aut
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| 245 |
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|a High levels of Crohn's disease-associated anti-microbial antibodies are present and independent of colitis in chronic granulomatous disease
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|c 2011
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 08.03.2011
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|a Date Revised 05.11.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2010 Elsevier Inc. All rights reserved.
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|a Chronic granulomatous disease (CGD) and inflammatory bowel disease (IBD) have overlapping gastrointestinal manifestations. Serum antibodies to intestinal microbial antigens in IBD are thought to reflect a loss of tolerance in the setting of genetically encoded innate immune defects. CGD subjects studied here, with or without colitis, had considerably higher levels of ASCA IgA, ASCA IgG, anti-OmpC, anti-I2, and anti-CBir1, but absent to low pANCA, compared to IBD-predictive cutoffs. Higher antibody levels were not associated with a history of colitis. Except for higher ASCA IgG in subjects <18 years, antibody levels were not age-dependent. In comparison, 7 HIES subjects expressed negative to low antibody levels to all of these antigens; none had colitis. Our results suggest that markedly elevated levels of antimicrobial antibodies in CGD do not correlate with a history of colitis but may reflect a specific defect in innate immunity in the face of chronic antigenic stimulation
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Research Support, N.I.H., Intramural
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| 650 |
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|a Antibodies, Antineutrophil Cytoplasmic
|2 NLM
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| 650 |
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|a Antibodies, Bacterial
|2 NLM
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| 650 |
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|a Antibodies, Fungal
|2 NLM
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| 650 |
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|a CBir1 flagellin
|2 NLM
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| 650 |
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|a OmpC protein
|2 NLM
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| 650 |
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|a Porins
|2 NLM
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|a Flagellin
|2 NLM
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| 650 |
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|a 12777-81-0
|2 NLM
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| 700 |
1 |
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|a De Ravin, Suk See
|e verfasserin
|4 aut
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| 700 |
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|a Uzel, Gulbu
|e verfasserin
|4 aut
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| 700 |
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|a Landers, Carol
|e verfasserin
|4 aut
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| 700 |
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|a Targan, Stephan
|e verfasserin
|4 aut
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| 700 |
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|a Malech, Harry L
|e verfasserin
|4 aut
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| 700 |
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|a Holland, Steven M
|e verfasserin
|4 aut
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|a Cao, Wenqing
|e verfasserin
|4 aut
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| 700 |
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|a Harpaz, Noam
|e verfasserin
|4 aut
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| 700 |
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|a Mayer, Lloyd
|e verfasserin
|4 aut
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| 700 |
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|a Cunningham-Rundles, Charlotte
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 138(2011), 1 vom: 15. Jan., Seite 14-22
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:138
|g year:2011
|g number:1
|g day:15
|g month:01
|g pages:14-22
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|u http://dx.doi.org/10.1016/j.clim.2010.08.003
|3 Volltext
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