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231223s2011 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2010.09.005
|2 doi
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|a pubmed24n0675.xml
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|a (DE-627)NLM20241700X
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|a (NLM)20951096
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Nemeth, Johannes
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Specific cytokine patterns of pulmonary tuberculosis in Central Africa
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| 264 |
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|c 2011
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 08.03.2011
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|a Date Revised 17.01.2011
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2010 Elsevier Inc. All rights reserved.
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|a Different cytokines have been suggested to be involved in the pathogenesis of pulmonary tuberculosis (TB). The frequencies of Mycobacterium tuberculosis (MTB) specific CD4(+) and CD8(+) T cells, CD4(+)CD25(+) Forkhead Box Protein (FoxP)3(+) T cells, interleukin (IL)-6, interferon (IFN)-γ, Tumor necrosis factor (TNF)-α, transforming growth factor (TGF)-β and IL-10 were assessed in HIV-negative, pulmonary tuberculosis (TB) patients (n=30) and in healthy controls (n=23) in Gabon. Peripheral blood mononuclear cells (PBMC) were stimulated with purified protein derivative (PPD) and early secretory antigenic target-6 (ESAT-6). In patients, a pronounced pro-inflammatory cytokine response with highly significant increased levels of IL-6 and TNF-α accompanied by increased TGF-β was detectable. Differences in IFN-γ responses between patients and healthy individuals were less pronounced than expected. FoxP3 expression did not differ between groups. A distinct cytokine pattern is associated with active pulmonary TB in patients from Central Africa
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|a Journal Article
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| 650 |
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|a Antigens, Bacterial
|2 NLM
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| 650 |
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|a Bacterial Proteins
|2 NLM
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| 650 |
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|a Cytokines
|2 NLM
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| 650 |
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7 |
|a ESAT-6 protein, Mycobacterium tuberculosis
|2 NLM
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| 650 |
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|a FOXP3 protein, human
|2 NLM
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| 650 |
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|a Forkhead Transcription Factors
|2 NLM
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| 650 |
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7 |
|a Hemoglobins
|2 NLM
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| 650 |
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7 |
|a IL10 protein, human
|2 NLM
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| 650 |
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7 |
|a IL6 protein, human
|2 NLM
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| 650 |
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7 |
|a Interleukin-2
|2 NLM
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| 650 |
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7 |
|a Interleukin-6
|2 NLM
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| 650 |
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7 |
|a Transforming Growth Factor beta
|2 NLM
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| 650 |
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7 |
|a Tuberculin
|2 NLM
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| 650 |
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7 |
|a Tumor Necrosis Factor-alpha
|2 NLM
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| 650 |
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7 |
|a Interleukin-10
|2 NLM
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| 650 |
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7 |
|a 130068-27-8
|2 NLM
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| 650 |
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7 |
|a Interferon-gamma
|2 NLM
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| 650 |
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7 |
|a 82115-62-6
|2 NLM
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| 700 |
1 |
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|a Winkler, Heide-Maria
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Boeck, Lucas
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Adegnika, Ayola A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Clement, Ella
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mve, Toung M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kremsner, Peter G
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Winkler, Stefan
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 138(2011), 1 vom: 26. Jan., Seite 50-9
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:138
|g year:2011
|g number:1
|g day:26
|g month:01
|g pages:50-9
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| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2010.09.005
|3 Volltext
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|a GBV_ILN_350
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|a AR
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| 952 |
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|d 138
|j 2011
|e 1
|b 26
|c 01
|h 50-9
|