A minimal implementation of the AMBER-GAUSSIAN interface for ab initio QM/MM-MD simulation

Copyright © 2010 Wiley Periodicals, Inc.

Bibliographische Detailangaben
Veröffentlicht in:Journal of computational chemistry. - 1984. - 32(2011), 5 vom: 15. Apr., Seite 932-42
1. Verfasser: Okamoto, Takuya (VerfasserIn)
Weitere Verfasser: Yamada, Kenta, Koyano, Yoshiyuki, Asada, Toshio, Koga, Nobuaki, Nagaoka, Masataka
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2011
Zugriff auf das übergeordnete Werk:Journal of computational chemistry
Schlagworte:Journal Article Research Support, Non-U.S. Gov't
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500 |a CommentIn: J Comput Chem. 2012 Jul 15;33(19):1643-4. doi: 10.1002/jcc.23003. - PMID 22570199 
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520 |a For applying to a number of theoretical methodologies based on an ab initio quantum mechanical/molecular mechanical (QM/MM) molecular dynamics method connecting AMBER9 with GAUSSIAN03, we have developed an AMBER-GAUSSIAN interface (AG-IF), which can be one of the simplest architectures. In the AG-IF, only a few subroutines addition is necessary to retrieve the QM/MM energy and forces, obtained by GAUSSIAN, for solving a set of Newtonian equations of motion in AMBER. It is, therefore, easy to be modified for individual applications since AG-IF utilizes most of those functions originally equipped not only in AMBER but also in GAUSSIAN. In the present minimal implementation, only AMBER is modified, whereas GAUSSIAN is left unchanged. Moreover, a different method of calculating electrostatic forces of MM atoms interacting with QM region is proposed. Using the AG-IF, we also demonstrate three examples of application: (i) the QM versus MM comparison in the radial distribution function, (ii) the free energy gradient method, and (iii) the charge from interaction energy and forces 
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700 1 |a Koyano, Yoshiyuki  |e verfasserin  |4 aut 
700 1 |a Asada, Toshio  |e verfasserin  |4 aut 
700 1 |a Koga, Nobuaki  |e verfasserin  |4 aut 
700 1 |a Nagaoka, Masataka  |e verfasserin  |4 aut 
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