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231223s2011 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2010.09.003
|2 doi
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|a pubmed24n0675.xml
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|a (DE-627)NLM202382362
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|a (NLM)20947433
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Liang, YanMei
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Toll-like receptor 2 induces mucosal homing receptor expression and IgA production by human B cells
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|c 2011
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 08.03.2011
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| 500 |
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|a Date Revised 07.04.2011
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright © 2010 Elsevier Inc. All rights reserved.
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|a There is a need for developing vaccines that elicit mucosal immunity. Although oral or nasal vaccination methods would be ideal, current strategies have yielded mixed success. Toll-like receptor 2 (TLR2) ligands are effective adjuvants and are currently used in the Haemophilus influenzae type B vaccine. Induction of humoral immunity in the mucosa is critical for effective vaccination; thus, we sought to determine the effects of TLR2 ligands on human mucosal B cell differentiation. We demonstrate that TLR2 ligands induce CCR9 and CCR10 expression by circulating B cells and increased chemotaxis to cognate chemokines CCL25 and CCL28 suggesting that TLR2 induces B cell homing to the gastrointestinal tract. TLR2 stimulation of B cells also induced J chain and IgA production demonstrating the induction of mucosal-like antibody secreting cells. These observations suggest that vaccines containing TLR2-ligands as adjuvants could induce mucosal B cell immunity even when delivered in a non-mucosal manner
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| 650 |
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|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a CC chemokine receptor 9
|2 NLM
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| 650 |
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|a CCL25 protein, human
|2 NLM
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| 650 |
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7 |
|a CCL28 protein, human
|2 NLM
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| 650 |
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|a CCR10 protein, human
|2 NLM
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| 650 |
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|a Chemokines, CC
|2 NLM
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| 650 |
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|a Immunoglobulin A
|2 NLM
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| 650 |
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7 |
|a Immunoglobulin J-Chains
|2 NLM
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| 650 |
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|a Immunoglobulin M
|2 NLM
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| 650 |
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7 |
|a Lipopolysaccharides
|2 NLM
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| 650 |
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7 |
|a Porins
|2 NLM
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| 650 |
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|a Receptors, CCR
|2 NLM
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| 650 |
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7 |
|a Receptors, CCR10
|2 NLM
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| 650 |
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7 |
|a Receptors, Lymphocyte Homing
|2 NLM
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| 650 |
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7 |
|a Toll-Like Receptor 2
|2 NLM
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| 650 |
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7 |
|a porin protein, Neisseria
|2 NLM
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| 650 |
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|a Interleukin-10
|2 NLM
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| 650 |
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7 |
|a 130068-27-8
|2 NLM
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| 700 |
1 |
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|a Hasturk, Hatice
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Elliot, Jennifer
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Noronha, Ansu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Xiuping
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wetzler, Lee M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Massari, Paola
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kantarci, Alpdogan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Winter, Harland S
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Farraye, Francis A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ganley-Leal, Lisa M
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 138(2011), 1 vom: 10. Jan., Seite 33-40
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:138
|g year:2011
|g number:1
|g day:10
|g month:01
|g pages:33-40
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2010.09.003
|3 Volltext
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|a GBV_ILN_350
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|a AR
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| 952 |
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|d 138
|j 2011
|e 1
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|c 01
|h 33-40
|