|
|
|
|
| LEADER |
01000caa a22002652c 4500 |
| 001 |
NLM202335216 |
| 003 |
DE-627 |
| 005 |
20250212025409.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231223s2010 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1021/la103095d
|2 doi
|
| 028 |
5 |
2 |
|a pubmed25n0674.xml
|
| 035 |
|
|
|a (DE-627)NLM202335216
|
| 035 |
|
|
|a (NLM)20942453
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Estephan, Zaki G
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Zwitterion-stabilized silica nanoparticles
|b toward nonstick nano
|
| 264 |
|
1 |
|c 2010
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 04.03.2011
|
| 500 |
|
|
|a Date Revised 16.11.2017
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a Using a short-chain zwitterionic organosiloxane, silica nanoparticles were stabilized against aggregation by high ionic strength and/or proteins. Turbidimetry and dynamic light scattering showed that "zwitterated" nanoparticles did not exhibit a significant increase in hydrodynamic radius. When challenged with 3 M NaCl or 50% fetal bovine serum, aggregation was inhibited for at least 24 h, longer with mild heat treatment, which produced nanoparticles with zero net surface charge. These findings suggest "zwitteration" of silica-capped nanoparticles provides excellent stability for in vivo circulation diagnostics and therapies
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
7 |
|a Siloxanes
|2 NLM
|
| 650 |
|
7 |
|a Betaine
|2 NLM
|
| 650 |
|
7 |
|a 3SCV180C9W
|2 NLM
|
| 650 |
|
7 |
|a Silicon Dioxide
|2 NLM
|
| 650 |
|
7 |
|a 7631-86-9
|2 NLM
|
| 650 |
|
7 |
|a sulfobetaine
|2 NLM
|
| 650 |
|
7 |
|a 8CVU22OCJW
|2 NLM
|
| 700 |
1 |
|
|a Jaber, Jad A
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Schlenoff, Joseph B
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1985
|g 26(2010), 22 vom: 16. Nov., Seite 16884-9
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnas
|
| 773 |
1 |
8 |
|g volume:26
|g year:2010
|g number:22
|g day:16
|g month:11
|g pages:16884-9
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1021/la103095d
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_22
|
| 912 |
|
|
|a GBV_ILN_350
|
| 912 |
|
|
|a GBV_ILN_721
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 26
|j 2010
|e 22
|b 16
|c 11
|h 16884-9
|