A case of leiomyosarcoma of prostate multimodality therapy suppressed disease progression for long term

A case of leiomyosarcoma of prostate : multimodality therapy suppressed disease progression for long term

A 67-year-old man presented with macroscopic hematuria. Transrectal prostatic needle biopsy was performed because of elevated prostate specific antigen (PSA) (3.85 ng/ml) and palpation of hard nodules at the prostate. Pathological diagnosis was leiomysarcoma. Computed tomography revealed several pul...

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Publié dans:Hinyokika kiyo. Acta urologica Japonica. - 1962. - 56(2010), 9 vom: 12. Sept., Seite 527-30
Auteur principal: Hayashi, Takuji (Auteur)
Autres auteurs: Nakai, Yasutomo, Kakuta, Youichi, Takayama, Hitoshi, Nakayama, Masashi, Nonomura, Norio, Okumi, Masayoshi, Nakao, Atsushi
Format: Article
Langue:Japanese
Publié: 2010
Accès à la collection:Hinyokika kiyo. Acta urologica Japonica
Sujets:Case Reports Journal Article Antimetabolites, Antineoplastic Antineoplastic Agents Taxoids Deoxycytidine 0W860991D6 Docetaxel 15H5577CQD Gemcitabine
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520 |a A 67-year-old man presented with macroscopic hematuria. Transrectal prostatic needle biopsy was performed because of elevated prostate specific antigen (PSA) (3.85 ng/ml) and palpation of hard nodules at the prostate. Pathological diagnosis was leiomysarcoma. Computed tomography revealed several pulmonary metastases. Radical cysto-prostatectomy and construction of ileal conduct were performed. Adjuvant radiotherapy (50 Gy) was also performed. During follow-up, the size of the pulmonary metastases increased, and we decided to start systemic chemotherapy 7 months after surgery. The chemotherapy consisted of gemcitabine (900 mg/m2 on day 1 and day 8), and docetaxel (100 mg/m2 on day 8). After eight courses, there was 20% reduction in the size of some pulmonary metastases. He remained alive 21 months after diagnosis 
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