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231223s2007 xx ||||| 00| ||eng c |
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|a (NLM)20930942
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Hwang, Taewon
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Anticancer Drug-Phospholipid Conjugate for Enhancement of Intracellular Drug Delivery
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| 264 |
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|c 2007
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Revised 02.05.2024
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|a published: Print
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|a Citation Status PubMed-not-MEDLINE
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|a Tumor specific delivery of anti-cancer drugs is one of the major challenges faced by drug development processes. In this study, we prepared a doxorubicin (DOX)-conjugated liposome (DCL) by incorporating the newly synthesized DSPE-PEG2000-DOX (DPD) into liposomes as a lipid component and tested its anti-tumor activity in vivo. DPD was synthesized by coupling DOX to DSPE-PEG2000-COOH via amide linkage and the chemical structure of resulting DPD was confirmed by (1)H-NMR analysis. DCL having liposome size of 130 nm was prepared through thin film cast-hydration method. DCL was found to have significantly higher cellular uptake than conventional liposomes as confirmed by flow cytometry analysis. Anti-tumor activity of DCL against murine B16F10 melanoma tumor-bearing mice revealed that DCL inhibits tumor growth more efficiently than the conventional liposomes, presumably attributed to DOX mediated endocytosis process
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| 650 |
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|a Journal Article
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| 700 |
1 |
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|a Han, Hee Dong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Song, Chung Kil
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Seong, Hasoo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kim, Jung Hyun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Xiaoyuan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shin, Byung Cheol
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Macromolecular symposia
|d 1999
|g 249-250(2007), 1 vom: 01. Apr., Seite 109-115
|w (DE-627)NLM098235508
|x 1022-1360
|7 nnns
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| 773 |
1 |
8 |
|g volume:249-250
|g year:2007
|g number:1
|g day:01
|g month:04
|g pages:109-115
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|a GBV_ILN_350
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|a AR
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| 952 |
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|d 249-250
|j 2007
|e 1
|b 01
|c 04
|h 109-115
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