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231223s2010 xx |||||o 00| ||eng c |
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|a 10.1021/la103066c
|2 doi
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|a eng
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|a Lidgi-Guigui, Nathalie
|e verfasserin
|4 aut
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| 245 |
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|a Investigation of DNA condensing properties of amphiphilic triblock cationic polymers by atomic force microscopy
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|c 2010
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|a Text
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|a ƒaComputermedien
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|a Date Completed 04.03.2011
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|a Date Revised 10.11.2010
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Introduction of nucleic acids into cells is an important biotechnology research field which also holds great promise for therapeutic applications. One of the key steps in the gene delivery process is compaction of DNA into nanometric particles. The study of DNA condensing properties of three linear cationic triblock copolymers poly(ethylenimine-b-propylene glycol-b-ethylenimine), namely, LPEI(50)-PPG(36)-LPEI(50), LPEI(19)-PPG(36)-LPEI(19), and LPEI(14)-PPG(68)-LPEI(14), indicates that proper DNA condensation is driven by both the charge and the size of the respective cationic hydrophilic linear polyethylenimine (LPEI) and neutral hydrophobic poly(propylene glycol) (PPG) parts. Atomic force microscopy was used to investigate the interactions of the triblock copolymers with plasmid DNA at the single molecule level and to enlighten the mechanism involved in DNA condensation
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|a Journal Article
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|a Polymers
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|a Solutions
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|a DNA
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|a 9007-49-2
|2 NLM
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|a Guis, Christine
|e verfasserin
|4 aut
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|a Brissault, Blandine
|e verfasserin
|4 aut
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|a Kichler, Antoine
|e verfasserin
|4 aut
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|a Leborgne, Christian
|e verfasserin
|4 aut
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|a Scherman, Daniel
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|a Labdi, Sid
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|a Curmi, Patrick A
|e verfasserin
|4 aut
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 26(2010), 22 vom: 16. Nov., Seite 17552-7
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|g volume:26
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|g day:16
|g month:11
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