Combinatorial and high-throughput screening of biomaterials
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
| Veröffentlicht in: | Advanced materials (Deerfield Beach, Fla.). - 1998. - 23(2011), 3 vom: 18. Jan., Seite 369-87 |
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| Format: | Online-Aufsatz |
| Sprache: | English |
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2011
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| Zugriff auf das übergeordnete Werk: | Advanced materials (Deerfield Beach, Fla.) |
| Schlagworte: | Journal Article Research Support, N.I.H., Extramural Review Biocompatible Materials Dental Materials Fibronectins Hydrogels Laminin Oligopeptides Polymers mehr... |
| Zusammenfassung: | Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Combinatorial and high-throughput methods have been increasingly used to accelerate research and development of new biomaterials. These methods involve creating miniaturized libraries that contain many specimens in one sample in the form of gradients or arrays, followed by automated data collection and analysis. This article reviews recent advances in utilizing combinatorial and high-throughput methods to better understand cell-material interactions, particularly highlighting our efforts at the NIST Polymers Division. Specifically, fabrication techniques to generate controlled surfaces (2D) and 3D cell environments (tissue engineering scaffolds) as well as methods to characterize and analyze material properties and cell-material interactions are described. In conclusion, additional opportunities for combinatorial methods for biomaterials research are noted, including streamlined sample fabrication and characterization, appropriate and automated bioassays, and data analysis |
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| Beschreibung: | Date Completed 12.04.2011 Date Revised 10.03.2022 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1521-4095 |
| DOI: | 10.1002/adma.201001763 |