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231223s2010 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2010.07.008
|2 doi
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|a pubmed24n0671.xml
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|a (DE-627)NLM201400782
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|a (NLM)20822960
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Kisielewicz, Anna
|e verfasserin
|4 aut
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| 245 |
1 |
2 |
|a A distinct subset of HLA-DR+-regulatory T cells is involved in the induction of preterm labor during pregnancy and in the induction of organ rejection after transplantation
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|c 2010
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 17.02.2011
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|a Date Revised 05.10.2010
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2010 Elsevier Inc. All rights reserved.
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|a Regulatory T cells (Tregs) are known to suppress alloimmune responses during pregnancy and post organ transplantation. We demonstrate that a distinct subset of FoxP3(+)DR(+)-Tregs among the total CD4(+)CD127(low+/-)CD25(+)-Treg cell pool is critically involved in preterm labor induction and kidney transplant rejection as well. Compared to healthy pregnancies and non-rejecting kidney recipients, we found that the percentage of the FoxP3(+)DR(+)-Treg subset was not reduced, but that the level of HLA-DR expression of such Tregs was strongly diminished in preterm laboring women and in patients with acute renal allograft rejection. In addition, both patient collectives showed a significantly reduced suppressive activity of their circulating CD4(+)CD127(low+/-)CD25(+)-Treg cell pool. Our findings propose that the FoxP3(+)DR(+)-Treg subset may be decisively responsible for the suppressive activity of the total CD4(+)CD127(low+/-)CD25(+)-Treg cell pool and that the immunologic mechanisms leading to preterm labor necessitating preterm delivery may be similar to those leading to allograft rejection after transplantation
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a FOXP3 protein, human
|2 NLM
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| 650 |
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7 |
|a Forkhead Transcription Factors
|2 NLM
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| 650 |
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|a HLA-DR Antigens
|2 NLM
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| 650 |
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|a IL2RA protein, human
|2 NLM
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| 650 |
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7 |
|a Interleukin-2 Receptor alpha Subunit
|2 NLM
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| 650 |
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7 |
|a Interleukin-7 Receptor alpha Subunit
|2 NLM
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| 700 |
1 |
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|a Schaier, Matthias
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Schmitt, Edgar
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hug, Friederike
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Haensch, Gertrud M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Meuer, Stefan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zeier, Martin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sohn, Christof
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Steinborn, Andrea
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 137(2010), 2 vom: 01. Nov., Seite 209-20
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:137
|g year:2010
|g number:2
|g day:01
|g month:11
|g pages:209-20
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2010.07.008
|3 Volltext
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|d 137
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|h 209-20
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