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231223s2010 xx |||||o 00| ||eng c |
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|a 10.1021/la1018339
|2 doi
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|a pubmed24n0671.xml
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|a DE-627
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|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Walter, Maria Astrid
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Triacetone triperoxide (TATP)
|b hapten design and development of antibodies
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| 264 |
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|c 2010
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 03.01.2011
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|a Date Revised 16.11.2017
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|a published: Print
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|a Citation Status MEDLINE
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|a Triacetone triperoxide (TATP), an improvised explosive, is a potential security threat because of its cost-efficient synthesis and the difficulty in detecting it. A highly selective antibody could provide the necessary specificity to the detection process. To obtain antibodies, a hapten made from acetone, hydrogen peroxide, and 7-oxooctanoic acid has been designed, synthesized, and confirmed by NMR that displays the utmost similarity to the analyte. The single-crystal X-ray structures of the solvated species TATP·methanol (1:1) and the TATP derivate were determined. In both compounds, the molecules exhibit D(3) symmetry and adopt a twisted boat-chair conformation. The hapten was coupled to bovine serum albumin, and mice were immunized. An immune response against TATP was elicited, and selective antibodies were detected in the mouse serum, which should be very useful for the development of a TATP biosensor system. An ELISA with a limit of detection for TATP of 65 μg L(-1) is shown
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Haptens
|2 NLM
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|a Heterocyclic Compounds, 1-Ring
|2 NLM
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| 650 |
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|a Peroxides
|2 NLM
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|a triacetone triperoxide
|2 NLM
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| 650 |
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|a 62T938ZGDD
|2 NLM
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| 700 |
1 |
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|a Pfeifer, Dietmar
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kraus, Werner
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Emmerling, Franziska
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Schneider, Rudolf J
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Panne, Ulrich
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Weller, Michael G
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 26(2010), 19 vom: 05. Okt., Seite 15418-23
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|x 1520-5827
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|g volume:26
|g year:2010
|g number:19
|g day:05
|g month:10
|g pages:15418-23
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|u http://dx.doi.org/10.1021/la1018339
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