Extremely prolonged HIV seroconversion associated with an MHC haplotype carrying disease susceptibility genes for antibody deficiency disorders

Bibliographische Detailangaben
Veröffentlicht in:	Clinical immunology (Orlando, Fla.). - 1999. - 137(2010), 2 vom: 07. Nov., Seite 199-208
1. Verfasser:	Padiglione, Alex (VerfasserIn)
Weitere Verfasser:	Aleksic, Eman, French, Martyn, Arnott, Alicia, Wilson, Kim M, Tippett, Emma, Kaye, Matthew, Gray, Lachlan, Ellett, Anne, Crane, Megan, Leslie, David E, Lewin, Sharon R, Breschkin, Alan, Birch, Chris, Gorry, Paul R, McPhee, Dale A, Crowe, Suzanne M
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2010
Zugriff auf das übergeordnete Werk:	Clinical immunology (Orlando, Fla.)
Schlagworte:	Case Reports Journal Article Research Support, Non-U.S. Gov't Antibodies Antibodies, Neutralizing HIV Antigens HIV Core Protein p24 Hepatitis A Vaccines Hepatitis B Vaccines Immunoglobulin G mehr... Influenza Vaccines RNA, Viral Receptors, CCR5

Beschreibung
Zusammenfassung:	Copyright © 2010 Elsevier Inc. All rights reserved. Severe immunodeficiency during primary human immunodeficiency virus (HIV) infection is unusual. Here, we characterized viral and immunological parameters in a subject presenting with Pneumocystis jirovecii pneumonia in the setting of prolonged primary HIV illness and delayed seroconversion. HIV antibody was only detected by enzyme-linked immunosorbent assay 12 months after presentation, and Western blot profiles remain indeterminate. Isolated virus was of R5 phenotype, exhibited poor viral fitness, but was otherwise unremarkable. Analysis of HIV antibody isotypes showed failure to mount a detectable HIV IgG response over nearly 2 years of infection, in particular IgG(1)- and IgG(3)-specific responses, despite normal responses to common infections and vaccines. Genetic analysis demonstrated homozygosity for part of an MHC haplotype containing susceptibility genes for common variable immunodeficiency (CVID) syndrome and other antibody deficiency disorders. Thus, a primary disorder of specific antibody production may explain exceptionally slow antibody development in an otherwise severe seroconversion illness. This highlights the need for multiparameter testing, in particular use of a fourth generation HIV test, for confirming HIV infection and underscores the importance of host factors in HIV pathogenesis
Beschreibung:	Date Completed 17.02.2011 Date Revised 25.11.2016 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-7035
DOI:	10.1016/j.clim.2010.07.003