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231223s2010 xx |||||o 00| ||eng c |
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|a 10.1021/la102084f
|2 doi
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|a pubmed24n0667.xml
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|a (NLM)20695538
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Nam, Yoon Sung
|e verfasserin
|4 aut
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| 245 |
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|a Nanosized emulsions stabilized by semisolid polymer interphase
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| 264 |
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|c 2010
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 22.11.2010
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|a Date Revised 10.08.2010
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|a published: Print
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|a Citation Status MEDLINE
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|a We introduce a new approach for stabilizing oil-in-water nanoemulsions using a semisolid interphase formed by the phase separation of amphiphilic block copolymers from the organic phase. This system is illustrated using an amphiphilic diblock copolymer, poly(ethylene oxide)-block-poly(epsilon-caprolactone) (PEO-b-PCL), with commonly used oils. PEO-b-PCL can be miscible with oil at elevated temperatures (70-80 degrees C); however, polymer/oil demixing occurs as the temperature drops below the melting temperature of PEO-b-PCL (approximately 55 degrees C). A homogeneous polymer/oil mixture was dispersed in water at 80 degrees C to generate embryonic emulsions, and then the emulsion size was reduced to a nanometer range through microfluidic homogenization. The structure of the generated nanoemulsions is irreversibly frozen as they are cooled down to ambient temperature. The nanoemulsions stabilized by PEO-b-PCL show the excellent colloidal stability against thermal and chemical stresses, exhibiting no significant changes in the size distribution during incubation for 4 months at ambient temperature or 10 days at 60 degrees C. This study demonstrates that PEO-b-PCL is an attractive emulsifying material for practical nanoemulsion formulations requiring structural stability under a broad range of conditions
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Emulsions
|2 NLM
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|a Polyesters
|2 NLM
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|a polyethylene oxide-polycaprolactone copolymer
|2 NLM
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| 700 |
1 |
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|a Kim, Jin-Woong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shim, Jongwon
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Han, Sang Hoon
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kim, Han Kon
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 26(2010), 16 vom: 17. Aug., Seite 13038-43
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
1 |
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|g volume:26
|g year:2010
|g number:16
|g day:17
|g month:08
|g pages:13038-43
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|u http://dx.doi.org/10.1021/la102084f
|3 Volltext
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