Application of a real-time, calculable limiting form of the Renyi entropy for molecular imaging of tumors

Previously, we reported new methods for ultrasound signal characterization using entropy, H(f); a generalized entropy, the Renyi entropy, I(f)(r); and a limiting form of Renyi entropy suitable for real-time calculation, I(f),(infinity). All of these quantities demonstrated significantly more sensiti...

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Veröffentlicht in:IEEE transactions on ultrasonics, ferroelectrics, and frequency control. - 1986. - 57(2010), 8 vom: 01. Aug., Seite 1890-5
1. Verfasser: Marsh, Jon N (VerfasserIn)
Weitere Verfasser: Wallace, Kirk D, McCarthy, John E, Wickerhauser, Mladen V, Maurizi, Brian N, Lanza, Gregory M, Wickline, Samuel A, Hughes, Michael S
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2010
Zugriff auf das übergeordnete Werk:IEEE transactions on ultrasonics, ferroelectrics, and frequency control
Schlagworte:Letter Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Contrast Media
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245 1 0 |a Application of a real-time, calculable limiting form of the Renyi entropy for molecular imaging of tumors 
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520 |a Previously, we reported new methods for ultrasound signal characterization using entropy, H(f); a generalized entropy, the Renyi entropy, I(f)(r); and a limiting form of Renyi entropy suitable for real-time calculation, I(f),(infinity). All of these quantities demonstrated significantly more sensitivity to subtle changes in scattering architecture than energy-based methods in certain settings. In this study, the real-time calculable limit of the Renyi entropy, I(f),(infinity), is applied for the imaging of angiogenic murine neovasculature in a breast cancer xenograft using a targeted contrast agent. It is shown that this approach may be used to reliably detect the accumulation of targeted nanoparticles at five minutes post-injection in this in vivo model 
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650 4 |a Research Support, N.I.H., Extramural 
650 4 |a Research Support, U.S. Gov't, Non-P.H.S. 
650 7 |a Contrast Media  |2 NLM 
700 1 |a Wallace, Kirk D  |e verfasserin  |4 aut 
700 1 |a McCarthy, John E  |e verfasserin  |4 aut 
700 1 |a Wickerhauser, Mladen V  |e verfasserin  |4 aut 
700 1 |a Maurizi, Brian N  |e verfasserin  |4 aut 
700 1 |a Lanza, Gregory M  |e verfasserin  |4 aut 
700 1 |a Wickline, Samuel A  |e verfasserin  |4 aut 
700 1 |a Hughes, Michael S  |e verfasserin  |4 aut 
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