Clinical analysis of 13 cases with growth hormone deficiency combined with pituitary stalk interruption

OBJECTIVE: To analyze the clinical characteristics of the patients with pituitary stalk interruption syndrome (PSIS), and to achieve better comprehension of this disease

Bibliographische Detailangaben
Veröffentlicht in:Zhonghua er ke za zhi = Chinese journal of pediatrics. - 1960. - 48(2010), 4 vom: 26. Apr., Seite 305-7
1. Verfasser: Wang, Gao-liang (VerfasserIn)
Weitere Verfasser: Fu, Jun-fen, Wang, Chun-lin, Liang, Li
Format: Aufsatz
Sprache:Chinese
Veröffentlicht: 2010
Zugriff auf das übergeordnete Werk:Zhonghua er ke za zhi = Chinese journal of pediatrics
Schlagworte:English Abstract Journal Article Human Growth Hormone 12629-01-5
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245 1 0 |a Clinical analysis of 13 cases with growth hormone deficiency combined with pituitary stalk interruption 
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500 |a Citation Status MEDLINE 
520 |a OBJECTIVE: To analyze the clinical characteristics of the patients with pituitary stalk interruption syndrome (PSIS), and to achieve better comprehension of this disease 
520 |a METHOD: Data of 13 patients with PSIS were retrospectively analyzed for the clinical, laboratory and imaging features 
520 |a RESULT: All the 13 patients (9 male, 4 female) had the chief complaint of growth retardation, 81.5 - 135.0 cm in body height, which were minus two standard deviations below the average of the normal children of same age and same sex. GH stimulated peak levels were all below 5 microg/L; Among them, one was accompanied by delayed sexual development, one by central diabetes insipidus, one was complicated with central hypothyroidism and one was accompanied by central adrenocortical hypofunction 
520 |a CONCLUSION: The most remarkable clinical manifestations of patients with PSIS were growth retardation, partial or complete adenohypophyseal dysfunction. MRI revealed absence of pituitary stalk or anterior pituitary hypoplasia with ectopic posterior pituitary gland 
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700 1 |a Fu, Jun-fen  |e verfasserin  |4 aut 
700 1 |a Wang, Chun-lin  |e verfasserin  |4 aut 
700 1 |a Liang, Li  |e verfasserin  |4 aut 
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