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231223s2010 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2010.06.011
|2 doi
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|a pubmed24n0665.xml
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Marron, Thomas U
|e verfasserin
|4 aut
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|a TLR signaling and effector functions are intact in XLA neutrophils
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|c 2010
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 07.12.2010
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|a Date Revised 23.02.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2010 Elsevier Inc. All rights reserved.
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|a Toll-like receptors (TLRs) are essential components of the innate immune system, and their ligands are important activators of neutrophils. Bruton's tyrosine kinase (Btk) has been reported to mediate signaling through toll-like receptors (TLRs) in many cell types, however, the role of Btk in TLR activation of neutrophils remains unclear. Impaired TLR-induced neutrophil function was found in mice with loss of Btk and in humans with TLR-signaling defects, but the integrity of TLR pathways in X-linked agammaglobulinemia (XLA) neutrophils has not been assessed. In this study LPS (TLR4) or an imidazoquinoline compound (TLR7/8) activated XLA neutrophil shedding of surface CD62L, and phosphorylated MAP kinases p38, JNK and ERK. TLR activation also induced normal respiratory burst and retarded apoptosis for XLA neutrophils, comparable to normal controls. These data demonstrate that the loss of Btk in XLA neutrophils does not impair functional responses to TLR signals
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Research Support, Non-U.S. Gov't
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|a CL097 compound
|2 NLM
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|a Imidazoles
|2 NLM
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|a Lipopolysaccharides
|2 NLM
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|a Quinolines
|2 NLM
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|a Reactive Oxygen Species
|2 NLM
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|a Toll-Like Receptors
|2 NLM
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|a L-Selectin
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|a Protein-Tyrosine Kinases
|2 NLM
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| 650 |
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|a EC 2.7.10.1
|2 NLM
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| 650 |
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|a Agammaglobulinaemia Tyrosine Kinase
|2 NLM
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| 650 |
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|a EC 2.7.10.2
|2 NLM
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| 650 |
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|a BTK protein, human
|2 NLM
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| 650 |
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|a EC 2.7.10.2
|2 NLM
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| 650 |
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|a Btk protein, mouse
|2 NLM
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| 650 |
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|a EC 2.7.10.2
|2 NLM
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| 650 |
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|a Mitogen-Activated Protein Kinases
|2 NLM
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| 650 |
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7 |
|a EC 2.7.11.24
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| 650 |
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7 |
|a NI40JAQ945
|2 NLM
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| 700 |
1 |
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|a Rohr, Kaileen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Martinez-Gallo, Monica
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yu, Joyce
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cunningham-Rundles, Charlotte
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 137(2010), 1 vom: 01. Okt., Seite 74-80
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|x 1521-7035
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|g volume:137
|g year:2010
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|g month:10
|g pages:74-80
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|u http://dx.doi.org/10.1016/j.clim.2010.06.011
|3 Volltext
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