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20231223214810.0 |
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231223s2010 xx |||||o 00| ||eng c |
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|a 10.1007/s10646-010-0518-8
|2 doi
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|a pubmed24n0665.xml
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|a (DE-627)NLM199508496
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|a (NLM)20623335
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Ducrot, Virginie
|e verfasserin
|4 aut
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|a Development of partial life-cycle experiments to assess the effects of endocrine disruptors on the freshwater gastropod Lymnaea stagnalis
|b a case-study with vinclozolin
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|c 2010
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 28.12.2010
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|a Date Revised 20.10.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Long-term effects of endocrine disruptors (EDs) on aquatic invertebrates remain difficult to assess, mainly due to the lack of appropriate sensitive toxicity test methods and relevant data analysis procedures. This study aimed at identifying windows of sensitivity to EDs along the life-cycle of the freshwater snail Lymnaea stagnalis, a candidate species for the development of forthcoming test guidelines. Juveniles, sub-adults, young adults and adults were exposed for 21 days to the fungicide vinclozolin (VZ). Survival, growth, onset of reproduction, fertility and fecundity were monitored weekly. Data were analyzed using standard statistical analysis procedures and mixed-effect models. No deleterious effect on survival and growth occurred in snails exposed to VZ at environmentally relevant concentrations. A significant impairment of the male function occurred in young adults, leading to infertility at concentrations exceeding 0.025 μg/L. Furthermore, fecundity was impaired in adults exposed to concentrations exceeding 25 μg/L. Biological responses depended on VZ concentration, exposure duration and on their interaction, leading to complex response patterns. The use of a standard statistical approach to analyze those data led to underestimation of VZ effects on reproduction, whereas effects could reliably be analyzed by mixed-effect models. L. stagnalis may be among the most sensitive invertebrate species to VZ, a 21-day reproduction test allowing the detection of deleterious effects at environmentally relevant concentrations of the fungicide. These results thus reinforce the relevance of L. stagnalis as a good candidate species for the development of guidelines devoted to the risk assessment of EDs
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Androgen Antagonists
|2 NLM
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|a Fungicides, Industrial
|2 NLM
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7 |
|a Oxazoles
|2 NLM
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| 650 |
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|a Water Pollutants, Chemical
|2 NLM
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| 650 |
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|a vinclozolin
|2 NLM
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| 650 |
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|a JJ258EZN1I
|2 NLM
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| 700 |
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|a Teixeira-Alves, Mickaël
|e verfasserin
|4 aut
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| 700 |
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|a Lopes, Christelle
|e verfasserin
|4 aut
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| 700 |
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|a Delignette-Muller, Marie-Laure
|e verfasserin
|4 aut
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|a Charles, Sandrine
|e verfasserin
|4 aut
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| 700 |
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|a Lagadic, Laurent
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Ecotoxicology (London, England)
|d 1992
|g 19(2010), 7 vom: 07. Okt., Seite 1312-21
|w (DE-627)NLM098212214
|x 1573-3017
|7 nnns
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| 773 |
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|g volume:19
|g year:2010
|g number:7
|g day:07
|g month:10
|g pages:1312-21
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|u http://dx.doi.org/10.1007/s10646-010-0518-8
|3 Volltext
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