Design of an in vivo cleavable disulfide linker in recombinant fusion proteins
In order to achieve optimal biological activity and desired pharmacokinetic profiles, a dithiocyclopeptide linker was designed for in vivo release of protein domains from a recombinant fusion protein. This novel in vivo cleavable disulfide linker, based on a dithiocyclopeptide containing a thrombin-...
Ausführliche Beschreibung
Bibliographische Detailangaben
| Veröffentlicht in: | BioTechniques. - 1988. - 49(2010), 1 vom: 06. Juli, Seite 513-8
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| 1. Verfasser: |
Chen, Xiaoying
(VerfasserIn) |
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| Weitere Verfasser: |
Bai, Yun,
Zaro, Jennica L,
Shen, Wei-Chiang |
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| Format: | Online-Aufsatz
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| Sprache: | English |
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| Veröffentlicht: |
2010
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| Zugriff auf das übergeordnete Werk: | BioTechniques
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| Schlagworte: | Journal Article
Research Support, N.I.H., Extramural
Disulfides
Peptides, Cyclic
Recombinant Fusion Proteins
Recombinant Proteins
Transferrin
Granulocyte Colony-Stimulating Factor
143011-72-7
Thrombin
EC 3.4.21.5 |
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