Enzymatic approaches and bisulfite sequencing cannot distinguish between 5-methylcytosine and 5-hydroxymethylcytosine in DNA
DNA cytosine methylation (5mC) is highly abundant in mammalian cells and is associated with transcriptional repression. Recently, hydroxymethylcytosine (hmC) has been detected at high levels in certain human cell types; however, its roles are unknown. Due to the structural similarity between 5mC and...
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Détails bibliographiques
| Publié dans: | BioTechniques. - 1991. - 48(2010), 4 vom: 01. Apr., Seite 317-9
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| Auteur principal: |
Nestor, Colm
(Auteur) |
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| Autres auteurs: |
Ruzov, Alexey,
Meehan, Richard,
Dunican, Donncha |
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| Format: | Article en ligne
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| Langue: | English |
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| Publié: |
2010
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| Accès à la collection: | BioTechniques
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| Sujets: | Journal Article
Research Support, Non-U.S. Gov't
Octamer Transcription Factor-3
POU5F1 protein, human
Sulfites
5-hydroxymethylcytosine
1123-95-1
5-Methylcytosine
6R795CQT4H
Cytosine
plus...
8J337D1HZY
DNA
9007-49-2
DNA Restriction Enzymes
EC 3.1.21.-
hydrogen sulfite
OJ9787WBLU |
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