Protein-lipid interactions at the air-water interface

Protein-lipid interactions play an important role in a variety of fields, for example in pharmaceutical research, biosensing, or food science. However, the underlying fundamental processes that govern the interplay of lipids and proteins are often very complex and are therefore studied using model s...

Ausführliche Beschreibung

Bibliographische Detailangaben
Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1992. - 26(2010), 14 vom: 20. Juli, Seite 12049-53
1. Verfasser: Junghans, Ann (VerfasserIn)
Weitere Verfasser: Champagne, Chlóe, Cayot, Philippe, Loupiac, Camille, Köper, Ingo
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2010
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Lactoglobulins Water 059QF0KO0R
LEADER 01000naa a22002652 4500
001 NLM198904606
003 DE-627
005 20231223213614.0
007 cr uuu---uuuuu
008 231223s2010 xx |||||o 00| ||eng c
024 7 |a 10.1021/la100036v  |2 doi 
028 5 2 |a pubmed24n0663.xml 
035 |a (DE-627)NLM198904606 
035 |a (NLM)20557079 
040 |a DE-627  |b ger  |c DE-627  |e rakwb 
041 |a eng 
100 1 |a Junghans, Ann  |e verfasserin  |4 aut 
245 1 0 |a Protein-lipid interactions at the air-water interface 
264 1 |c 2010 
336 |a Text  |b txt  |2 rdacontent 
337 |a ƒaComputermedien  |b c  |2 rdamedia 
338 |a ƒa Online-Ressource  |b cr  |2 rdacarrier 
500 |a Date Completed 01.12.2010 
500 |a Date Revised 21.11.2013 
500 |a published: Print 
500 |a Citation Status MEDLINE 
520 |a Protein-lipid interactions play an important role in a variety of fields, for example in pharmaceutical research, biosensing, or food science. However, the underlying fundamental processes that govern the interplay of lipids and proteins are often very complex and are therefore studied using model systems. Here, Langmuir monolayers were used to probe the interaction of a model protein with lipid films at the air-water interface. The protein beta-lactoglobulin (beta lg) is the major component in bovine milk serum, where it coexists with the milk fat globular membrane. During homogenization of milk, beta lg adsorbs to the interface of lipid fat globules and stabilizes the oil-in-water emulsion. pH and ionic strength of the subphase had a significant effect on the surface activity of the protein. Additionally, by using lipids with different charges, it could be shown that the interactions between beta lg and a phospholipid layer were driven by hydrophobic as well as by electrostatic interactions. beta lg preferentially interacted with phospholipids in an unfolded state. This could be either achieved by denaturation at the air-water interface or due to electrostatic interactions that weaken the intramolecular forces of the protein 
650 4 |a Journal Article 
650 7 |a Lactoglobulins  |2 NLM 
650 7 |a Water  |2 NLM 
650 7 |a 059QF0KO0R  |2 NLM 
700 1 |a Champagne, Chlóe  |e verfasserin  |4 aut 
700 1 |a Cayot, Philippe  |e verfasserin  |4 aut 
700 1 |a Loupiac, Camille  |e verfasserin  |4 aut 
700 1 |a Köper, Ingo  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Langmuir : the ACS journal of surfaces and colloids  |d 1992  |g 26(2010), 14 vom: 20. Juli, Seite 12049-53  |w (DE-627)NLM098181009  |x 1520-5827  |7 nnns 
773 1 8 |g volume:26  |g year:2010  |g number:14  |g day:20  |g month:07  |g pages:12049-53 
856 4 0 |u http://dx.doi.org/10.1021/la100036v  |3 Volltext 
912 |a GBV_USEFLAG_A 
912 |a SYSFLAG_A 
912 |a GBV_NLM 
912 |a GBV_ILN_22 
912 |a GBV_ILN_350 
912 |a GBV_ILN_721 
951 |a AR 
952 |d 26  |j 2010  |e 14  |b 20  |c 07  |h 12049-53