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231223s2010 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2010.04.016
|2 doi
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|a pubmed24n1395.xml
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|a (NLM)20472504
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|a DE-627
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|a eng
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| 100 |
1 |
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|a Rodriguez, Benigno
|e verfasserin
|4 aut
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| 245 |
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|a In vitro naïve T cell proliferation failure predicts poor post-immunization responses to neoantigen, but not recall antigens, in HIV-infection
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|c 2010
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 30.08.2010
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|a Date Revised 02.05.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright 2010 Elsevier Inc. All rights reserved.
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|a Immune reconstitution after HAART is incomplete, but no widely accepted method to quantify subclinical immune deficiency is available. We immunized 9 HIV-negative subjects and 29 HIV-infected patients with CD4>/=450 cells/microL and undetectable HIV RNA levels with 2 doses of diphtheria/tetanus toxoid (TT) and KLH, a presumed neoantigen. We quantified the response by lymphoproliferative assay, delayed-type hypersensitivity (DTH), and antibody titers up to 59days after enrollment. We assessed T cell proliferative capacity using anti-Vbeta3 and anti-Vbeta5 antibody stimulation, which we herein show induced predominant proliferation of naïve T cells. Subjects with detectable responses to KLH tended to exhibit greater proliferative responses to anti-Vbeta3/Vbeta5 stimulation; no such pattern was seen with response to TT. Several measures of in vitro T cell proliferative capacity correlated significantly with DTH and antibody responses to KLH, but not with TT responses; this association was independent of naïve T cell numbers. Our results indicate that naïve T cell proliferation predicts response to neo-, but not recall antigens, and suggest that it may be a meaningful reflection of in vivo immune competence in HIV-infected persons
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|a Journal Article
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|a Antigens
|2 NLM
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|a Tetanus Toxoid
|2 NLM
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|a Hemocyanins
|2 NLM
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| 700 |
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|a Valdez, Hernan
|e verfasserin
|4 aut
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1 |
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|a Lange, Christoph G
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Asaad, Robert
|e verfasserin
|4 aut
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|a Medvik, Kathy
|e verfasserin
|4 aut
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| 700 |
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|a Sieg, Scott F
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 136(2010), 3 vom: 16. Sept., Seite 400-8
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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|g volume:136
|g year:2010
|g number:3
|g day:16
|g month:09
|g pages:400-8
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|u http://dx.doi.org/10.1016/j.clim.2010.04.016
|3 Volltext
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