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231223s2010 xx |||||o 00| ||eng c |
| 024 |
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|a 10.1021/la101039w
|2 doi
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| 041 |
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|a eng
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| 100 |
1 |
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|a Niikura, Kenichi
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Influence of hydrophobic structures on the plasma membrane permeability of lipidlike molecules
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|c 2010
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 31.08.2010
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|a Date Revised 21.11.2013
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|a published: Print
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|a Citation Status MEDLINE
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|a A series of FITC-labeled hydrophobic molecules (1-8) were prepared, and their cellular uptakes have been investigated using cell-cycle-synchronized HeLa cells. The cellular membrane permeability of compounds strongly depended on both the chemical structure and the cell-cycle phase. In the G1/S phase, branched hydrocarbon-containing 3 and cis-olefin-containing 2 and 8 were efficiently internalized into cells by passive diffusion. In contrast, linear alkyl chain-containing 1 and 7 were retained on the membrane without rapid internalization. In the M phase, rapid permeation was suppressed for all molecules
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Hydrocarbons
|2 NLM
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|a Fluorescein-5-isothiocyanate
|2 NLM
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| 650 |
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|a I223NX31W9
|2 NLM
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| 700 |
1 |
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|a Nambara, Katsuyuki
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Okajima, Takaharu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Matsuo, Yasutaka
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ijiro, Kuniharu
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 26(2010), 12 vom: 15. Juni, Seite 9170-5
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|x 1520-5827
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|g volume:26
|g year:2010
|g number:12
|g day:15
|g month:06
|g pages:9170-5
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|u http://dx.doi.org/10.1021/la101039w
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