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01000naa a22002652 4500 |
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DE-627 |
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20231223211827.0 |
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cr uuu---uuuuu |
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231223s2010 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2010.04.003
|2 doi
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|a pubmed24n0660.xml
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|a (DE-627)NLM198018223
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|a (NLM)20462799
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Srivastava, Shivani
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Monocytes are resistant to apoptosis in systemic juvenile idiopathic arthritis
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| 264 |
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|c 2010
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 05.08.2010
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|a Date Revised 11.03.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a We investigated whether circulating monocytes from patients with systemic juvenile idiopathic arthritis (SJIA) are resistant to apoptosis and which apoptotic pathway(s) may mediate this resistance. A microarray analysis of peripheral blood mononuclear cells (PBMC) of SJIA samples and RT-PCR analysis of isolated monocytes showed that monocytes from active SJIA patients express transcripts that imply resistance to apoptosis. SJIA monocytes incubated in low serum show reduced annexin binding and diminished FasL up-regulation compared to controls. SJIA monocytes are less susceptible to anti-Fas-induced apoptosis and, upon activation of the mitochondrial pathway with staurosporine, show diminished Bid cleavage and Bcl-w down-regulation compared to controls. Exposure to SJIA plasma reduces responses to apoptotic triggers in normal monocytes. Thus, SJIA monocytes are resistant to apoptosis due to alterations in both the extrinsic and intrinsic apoptosis pathways, and circulating factors associated with active SJIA may confer this phenotype
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| 650 |
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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|a Antibodies
|2 NLM
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| 650 |
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|a FASLG protein, human
|2 NLM
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| 650 |
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|a Fas Ligand Protein
|2 NLM
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| 650 |
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|a fas Receptor
|2 NLM
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| 700 |
1 |
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|a Macaubas, Claudia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Deshpande, Chetan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Alexander, Heather C
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chang, Sheng-Yung
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sun, Yue
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Park, Jane L
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lee, Tzielan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Begovich, Ann
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mellins, Elizabeth D
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 136(2010), 2 vom: 01. Aug., Seite 257-68
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:136
|g year:2010
|g number:2
|g day:01
|g month:08
|g pages:257-68
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2010.04.003
|3 Volltext
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