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231223s2010 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2010.01.005
|2 doi
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|a pubmed24n0660.xml
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|a (DE-627)NLM19791098X
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|a (NLM)20451460
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
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|a Foster, Anthony D
|e verfasserin
|4 aut
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| 245 |
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|a Donor CD8 T cell activation is critical for greater renal disease severity in female chronic graft-vs.-host mice and is associated with increased splenic ICOS(hi) host CD4 T cells and IL-21 expression
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|c 2010
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 06.08.2010
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|a Date Revised 20.10.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a (c) 2010 Elsevier Inc. All rights reserved.
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|a Lupus-like renal disease in DBA/2-into-F1 (DBA --> F1) mice is driven by donor CD4 T cells and is more severe in females. Donor CD8 T cells have no known role. As expected, we observed that females receiving unfractionated DBA splenocytes (CD8 intact --> F1) exhibited greater clinical and histological severities of renal disease at 13 weeks compared to males. Surprisingly, sex-based differences in renal disease severity were lost in CD8 depleted --> F1 mice due to an improvement in females and a worsening in males. CD8 intact --> F1 female mice exhibited significantly greater donor and host effector (CD44(hi), CD62L(lo)) CD4 T cells and ICOS(hi) CD4 T follicular helper cells than males. CD8 depleted --> F1 female mice exhibited a reduction in the absolute numbers of host, but not donor CD4 Tfh cells and lost the significant increase in host CD4 effector cells vs. males. Greater female IL-21 expression, a product of Tfh cells, was seen in CD8 intact --> F1 and although reduced was still greater than male CD8 depleted --> F1 mice. Thus, donor CD8 T cells have a critical role in mediating sex-based differences in lupus renal disease severity possibly through greater host ICOS(hi) CD4 T cell involvement
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Antibodies, Antinuclear
|2 NLM
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|a Antigens, CD
|2 NLM
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|a Antigens, Differentiation, T-Lymphocyte
|2 NLM
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|a Icos protein, mouse
|2 NLM
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|a Immunoglobulin G
|2 NLM
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|a Inducible T-Cell Co-Stimulator Protein
|2 NLM
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| 650 |
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|a Interleukins
|2 NLM
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|a Serum Albumin
|2 NLM
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|a Triglycerides
|2 NLM
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|a Cholesterol
|2 NLM
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| 650 |
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|a 97C5T2UQ7J
|2 NLM
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|a interleukin-21
|2 NLM
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| 650 |
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|a MKM3CA6LT1
|2 NLM
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| 700 |
1 |
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|a Haas, Mark
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Puliaeva, Irina
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Soloviova, Kateryna
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Puliaev, Roman
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Via, Charles S
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 136(2010), 1 vom: 01. Juli, Seite 61-73
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:136
|g year:2010
|g number:1
|g day:01
|g month:07
|g pages:61-73
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2010.01.005
|3 Volltext
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|d 136
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|h 61-73
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