Effects of the novel immunosuppressant FTY720 in a murine rheumatoid arthritis model

We investigated the effects and mechanisms by which FTY720 (FTY) inhibits arthritis development in the SKG mouse rheumatoid arthritis (RA) model. FTY (1mg/kg/day) administration suppressed the progression of laminarin-induced arthritis in SKG mice. FTY treatment decreased IL-6 and TNF-alpha expressi...

Ausführliche Beschreibung

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 136(2010), 2 vom: 15. Aug., Seite 197-204
1. Verfasser: Tsunemi, Sachi (VerfasserIn)
Weitere Verfasser: Iwasaki, Tsuyoshi, Kitano, Sachie, Imado, Takehito, Miyazawa, Keiji, Sano, Hajime
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2010
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Cytokines Glucans Immunosuppressive Agents Polysaccharides Propylene Glycols Interleukin-4 207137-56-2 laminaran mehr... 9008-22-4 Fingolimod Hydrochloride G926EC510T Dinoprostone K7Q1JQR04M Sphingosine NGZ37HRE42