Functionalizable and ultrastable zwitterionic nanogels

Multifunctional biomimetic nanogels based on zwitterionic poly(carboxybetaine methacrylate) (pCBMA) were synthesized by inverse microemulsion free-radical polymerization. pCBMA nanogels exhibited excellent stability in 100% fetal bovine serum. Dextran labeled with fluorescein isothiocyanate (FITC-de...

Ausführliche Beschreibung

Bibliographische Detailangaben
Veröffentlicht in:	Langmuir : the ACS journal of surfaces and colloids. - 1992. - 26(2010), 10 vom: 18. Mai, Seite 6883-6
1. Verfasser:	Cheng, Gang (VerfasserIn)
Weitere Verfasser:	Mi, Luo, Cao, Zhiqiang, Xue, Hong, Yu, Qiuming, Carr, Louisa, Jiang, Shaoyi
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2010
Zugriff auf das übergeordnete Werk:	Langmuir : the ACS journal of surfaces and colloids
Schlagworte:	Journal Article Research Support, U.S. Gov't, Non-P.H.S. Dextrans Drug Carriers Ligands Nanogels polyethylene glycol polyethyleneimine nanogel Polyethylene Glycols 3WJQ0SDW1A Polyethyleneimine mehr... 9002-98-6 Fluorescein-5-isothiocyanate I223NX31W9

Beschreibung
Zusammenfassung:	Multifunctional biomimetic nanogels based on zwitterionic poly(carboxybetaine methacrylate) (pCBMA) were synthesized by inverse microemulsion free-radical polymerization. pCBMA nanogels exhibited excellent stability in 100% fetal bovine serum. Dextran labeled with fluorescein isothiocyanate (FITC-dextran) was encapsulated in nanogels as a model drug. Encapsulated FITC-dextran exhibited controlled release from the pCBMA nanogel. Additionally, pCBMA nanogels carry abundant carboxylate groups as functional groups used to conjugate ligands to the nanogels for targeted drug delivery. Flow cytometry results obtained showed that pCBMA nanogels conjugated with cyclo[Arg-Gly-Asp-D-Tyr-Lys] ligands dramatically improved the nanogel uptake by primary human umbilical vein endothelium cells. Functionalizable zwitterionic pCBMA nanogels hold great potential as targeted drug-delivery vectors for biomedical applications
Beschreibung:	Date Completed 17.08.2010 Date Revised 10.12.2019 published: Print Citation Status MEDLINE
ISSN:	1520-5827
DOI:	10.1021/la100664g