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231223s2010 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2010.02.022
|2 doi
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|a pubmed24n0656.xml
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|a (DE-627)NLM196921198
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|a (NLM)20346734
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Xu, Jun-Fa
|e verfasserin
|4 aut
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|a Ectopic B7-H4-Ig expression attenuates concanavalin A-induced hepatic injury
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|c 2010
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 06.08.2010
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|a Date Revised 16.11.2017
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a (c) 2010 Elsevier Inc. All rights reserved.
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|a Previous studies demonstrate that both membrane B7-H4 and B7-H4-Ig fusion protein could inhibit T-cell responses. In the present study, we explored the potential effect of B7-H4-Ig on liver injury in a hepatitis mouse model induced by concanavalin A (ConA). A B7-H4-Ig construct was introduced into animals by the hydrodynamic gene delivery approach. It was found that ectopic expression of B7-H4-Ig could inhibit ConA-induced elevation of serum levels of ALT and AST, suppress liver necrosis and even mortality of mice. Furthermore, we observed that pretreatment of B7-H4-Ig dramatically decreased serum levels and the expression of mRNA for IL-2, IFN-gamma and IL-4, but increased IL-10 in ConA-treated mice. Our results suggest that B7-H4-Ig may protect animals from liver injury induced by ConA, which could be associated with reduced serum levels for IL-2, IFN-gamma and IL-4 as well as enhanced IL-10 production
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a B7-1 Antigen
|2 NLM
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| 650 |
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|a Immunoglobulin Fc Fragments
|2 NLM
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| 650 |
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|a Immunoglobulin G
|2 NLM
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| 650 |
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|a Interleukin-2
|2 NLM
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| 650 |
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|a Recombinant Fusion Proteins
|2 NLM
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| 650 |
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|a V-Set Domain-Containing T-Cell Activation Inhibitor 1
|2 NLM
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| 650 |
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|a Vtcn1 protein, mouse
|2 NLM
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| 650 |
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|a Concanavalin A
|2 NLM
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| 650 |
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|a 11028-71-0
|2 NLM
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| 650 |
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|a Interleukin-10
|2 NLM
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| 650 |
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|a 130068-27-8
|2 NLM
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| 650 |
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|a Interleukin-4
|2 NLM
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| 650 |
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|a 207137-56-2
|2 NLM
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| 650 |
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|a Interferon-gamma
|2 NLM
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| 650 |
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|a 82115-62-6
|2 NLM
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| 650 |
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|a Aspartate Aminotransferases
|2 NLM
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| 650 |
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|a EC 2.6.1.1
|2 NLM
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| 650 |
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|a Alanine Transaminase
|2 NLM
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| 650 |
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|a EC 2.6.1.2
|2 NLM
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| 700 |
1 |
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|a Xiao, Huan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hu, Guo-Yan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zheng, Shu-Hua
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Wei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yuan, Chun-Lei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Heng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lü, Jing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zheng, Fang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Cong-Yi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gong, Fei-Li
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 136(2010), 1 vom: 23. Juli, Seite 30-41
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:136
|g year:2010
|g number:1
|g day:23
|g month:07
|g pages:30-41
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2010.02.022
|3 Volltext
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