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231223s2010 xx |||||o 00| ||eng c |
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|a 10.1002/mrc.2580
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|a eng
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|a Dolenský, Bohumil
|e verfasserin
|4 aut
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|a Trifluoromethylated (tetrahydropyrrolo) quinazolinones by a new three-component reaction and facile assignment of the regio- and stereoisomers formed by NMR spectroscopy
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|c 2010
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|a Text
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|a ƒaComputermedien
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|a Date Completed 12.07.2010
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|a Date Revised 21.11.2013
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|a published: Print
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|a Citation Status MEDLINE
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|a Copyright 2010 John Wiley & Sons, Ltd.
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|a A new three-component cyclisation reactions of methyl 3,3,3-trifluoropyruvate, 2-aminobenzylamine and oxo compounds afforded tetrahydropyrroloquinazolinones of the types 4 and 5 as mixtures of regio- and stereoisomers. Whereas standard 1D NMR spectroscopy was used for a facile assignment of the cyclization regioisomers, a combination of homo (proton-proton) and heteronuclear (proton-fluorine) NOE experiments allowed the determination of the relative configuration on stereogenic centres. The structure of some compounds was also confirmed by the X-ray diffraction. Adaptation of the 1D double-pulsed field-gradient spin-echo NOE for a heteronuclear case is presented
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Quinazolinones
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|a Fluorine
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|a Kvícala, Jaroslav
|e verfasserin
|4 aut
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|a Paleta, Oldrich
|e verfasserin
|4 aut
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|a Lang, Jan
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|a Dvoráková, Hana
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|a Cejka, Jan
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|t Magnetic resonance in chemistry : MRC
|d 1985
|g 48(2010), 5 vom: 01. Mai, Seite 375-85
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|g volume:48
|g year:2010
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|g day:01
|g month:05
|g pages:375-85
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