Phospholipid complexation of general anesthetics in fluid bilayers

A nearest-neighbor recognition analysis has been performed in cholesterol-rich and cholesterol-poor liposomes derived from 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) in the presence of varying concentrations of chloroform. This analysis has yielded a fundamentally new, molecular-level view o...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1992. - 26(2010), 8 vom: 20. Apr., Seite 5309-11
1. Verfasser: Turkyilmaz, Serhan (VerfasserIn)
Weitere Verfasser: Mitomo, Hideyuki, Chen, Wen-Hua, Regen, Steven L
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2010
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Research Support, N.I.H., Extramural Anesthetics, General Lipid Bilayers Liposomes Phospholipids Chloroform 7V31YC746X Cholesterol 97C5T2UQ7J
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520 |a A nearest-neighbor recognition analysis has been performed in cholesterol-rich and cholesterol-poor liposomes derived from 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) in the presence of varying concentrations of chloroform. This analysis has yielded a fundamentally new, molecular-level view of the interaction of general anesthetics with lipid bilayers, which may be relevant to their biological action; that is, DPPC forms 1:1 complexes with CHCl(3) in both membranes in the fluid bilayer state 
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650 4 |a Research Support, N.I.H., Extramural 
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650 7 |a Lipid Bilayers  |2 NLM 
650 7 |a Liposomes  |2 NLM 
650 7 |a Phospholipids  |2 NLM 
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700 1 |a Chen, Wen-Hua  |e verfasserin  |4 aut 
700 1 |a Regen, Steven L  |e verfasserin  |4 aut 
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