|
|
|
|
| LEADER |
01000caa a22002652 4500 |
| 001 |
NLM195728866 |
| 003 |
DE-627 |
| 005 |
20250211082831.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231223s2010 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1021/la100540q
|2 doi
|
| 028 |
5 |
2 |
|a pubmed25n0652.xml
|
| 035 |
|
|
|a (DE-627)NLM195728866
|
| 035 |
|
|
|a (NLM)20222693
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Klimakow, Maria
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Combined synchrotron XRD/Raman measurements
|b in situ identification of polymorphic transitions during crystallization processes
|
| 264 |
|
1 |
|c 2010
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 30.09.2010
|
| 500 |
|
|
|a Date Revised 30.06.2010
|
| 500 |
|
|
|a published: Print
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a A combination of two analytical methods, time-resolved X-ray diffraction (XRD) and Raman spectroscopy, is presented as a novel tool for crystallization studies. An acoustic levitator was employed as sample environment. This setup enables the acquisition of XRD and Raman data in situ simultaneously within a 20 s period and hence permits investigation of polymorphic phase transitions during the crystallization process in different solvents (methanol, ethanol, acetone, dichloromethane, acetonitrile). These real time measurements allow the determination of the phase content from the onset of the first crystalline molecular assemblies to the stable system. To evaluate the capability of this approach, the setup was applied to elucidate the crystallization process of the polymorphic compound nifedipine. The results indicate the existence of solvent-dependent transient phases during the crystallization process. The quality of the data allowed the assignment of the lattice constants of the hitherto unknown crystal structure of the beta-polymorph
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 700 |
1 |
|
|a Leiterer, Jork
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Kneipp, Janina
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Rössler, Ernst
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Panne, Ulrich
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Rademann, Klaus
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Emmerling, Franziska
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1991
|g 26(2010), 13 vom: 06. Juli, Seite 11233-7
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
|
| 773 |
1 |
8 |
|g volume:26
|g year:2010
|g number:13
|g day:06
|g month:07
|g pages:11233-7
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1021/la100540q
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_22
|
| 912 |
|
|
|a GBV_ILN_350
|
| 912 |
|
|
|a GBV_ILN_721
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 26
|j 2010
|e 13
|b 06
|c 07
|h 11233-7
|