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NLM19544972X |
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DE-627 |
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20231223202804.0 |
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tu |
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231223s2009 xx ||||| 00| ||chi c |
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|a pubmed24n0652.xml
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|a (DE-627)NLM19544972X
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|a (NLM)20193149
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a chi
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| 100 |
1 |
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|a Liang, Xiao-ling
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Clinical study on childhood acute lymphoblastic leukemia diagnosed and treated with 04 Protocol in Chongqing, China
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| 264 |
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1 |
|c 2009
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 04.01.2011
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| 500 |
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|a Date Revised 07.06.2016
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a OBJECTIVE: To analyze the clinical and laboratory data from acute lymphoblastic leukemia (ALL) patients and the results of treatment using 04 Protocol (suggested by the Pediatric Hematology Group of Chinese Medical Association in 2004)
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| 520 |
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|a METHODS: This study included 88 children with ALL below the age of 18 years during the period from October 1, 2004 to June 30, 2007. Minimal inhibitory concentration (MIC) and clinical risk classification were done and the new chemotherapy regimen was used according to the protocol. Patients were stratified into low-risk (LR), medium-risk (MR), and high-risk (HR) groups. Life table method was used to estimate survival rate and statistical analysis was done by using software SPSS for Windows
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| 520 |
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|a RESULTS: From October 2004 to June 2007, 88 childhood ALL patients were treated with the 04 Protocol. Sixty-three (91.30%) patients attained complete remission (CR) and 17 patients lost to follow up. The overall 4-year-event-free survival (EFS) rate (+/- SE) was (59.73 +/- 7.22)%. EFS was (75.60 +/- 9.71)% in the LR (n = 30), (65.50 +/- 11.69)% in the MR (n = 20) and (44.03 +/- 12.36)% in the HR. Relapse occurred in 18.18% of patients. Seven (7.95%) of 88 patients with ALL died during he induction therapy. Infection was the most common cause of death
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| 520 |
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|a CONCLUSION: The outcome of patients treated with the 04 Protocol was favorable. Clinical risk classification and the leukemia cells of D19 are independent predictors of prognosis of ALL. High dose methotrexate played an important role in prevention and treatment of central nervous system leukemia. The mortality rate of this chemotherapeutic protocol during induction therapy was high
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| 650 |
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4 |
|a English Abstract
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| 650 |
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4 |
|a Journal Article
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| 700 |
1 |
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|a Xian, Ying
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dai, Bi-tao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xu, You-hua
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Su, Yong-chun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Shi-yi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lu, Ling-ling
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Xin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yu, Jie
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Zhonghua er ke za zhi = Chinese journal of pediatrics
|d 1960
|g 47(2009), 12 vom: 02. Dez., Seite 939-41
|w (DE-627)NLM136249191
|x 0578-1310
|7 nnns
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| 773 |
1 |
8 |
|g volume:47
|g year:2009
|g number:12
|g day:02
|g month:12
|g pages:939-41
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