Direct Charged-Particle Imaging System Using an Ultra-Thin Phosphor : Physical Characterization and Dynamic Applications
Imaging β rays in vivo will help to advance microdosimetry and radiopharmaceutical development. In an earlier paper [1], we reported a newly developed system capable of directly imaging high-energy electron emissions in small animals in vivo. In this paper, we have thoroughly characterized the perfo...
| Veröffentlicht in: | IEEE transactions on nuclear science. - 1988. - 56(2009), 5 vom: 06. Okt., Seite 2628-2635 |
|---|---|
| 1. Verfasser: | |
| Weitere Verfasser: | , , , |
| Format: | Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2009
|
| Zugriff auf das übergeordnete Werk: | IEEE transactions on nuclear science |
| Schlagworte: | Journal Article |
| Zusammenfassung: | Imaging β rays in vivo will help to advance microdosimetry and radiopharmaceutical development. In an earlier paper [1], we reported a newly developed system capable of directly imaging high-energy electron emissions in small animals in vivo. In this paper, we have thoroughly characterized the performance of the system. We have measured the sensitivity and detectability and the spatial resolution at various magnifications, as well as the linearity of the system. The system has also demonstrated the capability of directly detecting conversion electrons and positrons as well as β rays. The system has been applied to dynamically image spatiotemporal (18)F-Fluorodeoxyglucose (FDG) uptake distributions in xenograft small tumors in dorsal window chambers on mice in vivo. Heterogeneity in FDG uptake in millimeter-sized tumors has been observed |
|---|---|
| Beschreibung: | Date Revised 20.10.2021 published: Print Citation Status PubMed-not-MEDLINE |
| ISSN: | 0018-9499 |