Cholesterol Supplementation During Production Increases the Infectivity of Retroviral and Lentiviral Vectors Pseudotyped with the Vesicular Stomatitis Virus Glycoprotein (VSV-G)

Cholesterol, a major component of plasma membrane lipid rafts, is important for assembly and budding of enveloped viruses, including influenza and HIV-1. Cholesterol depletion impairs virus assembly and infectivity. This study examined the effects of exogenous cholesterol addition (delivered as a co...

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Veröffentlicht in:Biochemical engineering journal. - 1998. - 44(2009), 2-3 vom: 15. Mai, Seite 199-207
1. Verfasser: Chen, Yong (VerfasserIn)
Weitere Verfasser: Ott, Christopher J, Townsend, Kay, Subbaiah, Papasani, Aiyar, Ashok, Miller, William M
Format: Aufsatz
Sprache:English
Veröffentlicht: 2009
Zugriff auf das übergeordnete Werk:Biochemical engineering journal
Schlagworte:Journal Article