Evaluation of the radial deformability of poly(dG)-poly(dC) DNA and G4-DNA using vibrating scanning polarization force microscopy

Poly(dG)-poly(dC) DNA and G4-DNA are two types of synthetic molecules that are regarded as promising candidates for molecular nanodevices. In this work, vibrating scanning polarization force microscopy (VSPFM) was employed to study the radial deformability of these two molecules coadsorbed on a Ni(2...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1992. - 26(2010), 10 vom: 18. Mai, Seite 7523-8
1. Verfasser: Wang, Huabin (VerfasserIn)
Weitere Verfasser: Lin, Jiwei, Wang, Chunmei, Zhang, Xuehua, An, Hongjie, Zhou, Xingfei, Sun, Jielin, Hu, Jun
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2010
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Evaluation Study Journal Article Research Support, Non-U.S. Gov't Polydeoxyribonucleotides poly(dC-dG) 29855-95-6 DNA 9007-49-2
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520 |a Poly(dG)-poly(dC) DNA and G4-DNA are two types of synthetic molecules that are regarded as promising candidates for molecular nanodevices. In this work, vibrating scanning polarization force microscopy (VSPFM) was employed to study the radial deformability of these two molecules coadsorbed on a Ni(2+)-modified mica surface. The values of the radial compressive elastic modulus of these two types of molecules were found to be similar (approximately 5-10 MPa) when the external loading force was between approximately 0.04 and approximately 0.12 nN. However, G4-DNA molecules possessed higher stiffness than poly(dG)-poly(dC) DNA (approximately 20-40 vs approximately 10-20 MPa) when the loading force was larger than approximately 0.12 nN. The results will aid us in understanding these molecule's mechanical performances 
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650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
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700 1 |a Lin, Jiwei  |e verfasserin  |4 aut 
700 1 |a Wang, Chunmei  |e verfasserin  |4 aut 
700 1 |a Zhang, Xuehua  |e verfasserin  |4 aut 
700 1 |a An, Hongjie  |e verfasserin  |4 aut 
700 1 |a Zhou, Xingfei  |e verfasserin  |4 aut 
700 1 |a Sun, Jielin  |e verfasserin  |4 aut 
700 1 |a Hu, Jun  |e verfasserin  |4 aut 
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