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01000caa a22002652 4500 |
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NLM194528952 |
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DE-627 |
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20250211052553.0 |
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tu |
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231223s2010 xx ||||| 00| ||chi c |
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|a pubmed25n0648.xml
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|a (DE-627)NLM194528952
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|a (NLM)20092704
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a chi
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| 100 |
1 |
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|a Wen, Qiang
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Role of assessment and monitoring of human leucocyte antigen-DR on CD14+ monocyte in postoperative infection in patients after orthotopic liver transplantation
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|c 2010
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 05.05.2011
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|a Date Revised 16.11.2017
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a OBJECTIVE: To investigate the changes in expression level of human leucocyte antigen-DR (HLA-DR) on CD14(+) monocyte (CD14(+)/HLA-DR) in the patients after orthotopic liver transplantation, and its role in monitoring postoperative infection
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| 520 |
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|a METHODS: Sixty-three patients with liver transplantation were divided into three groups, non-infection group with 47 cases, infection group with 10 cases and septic shock group with 6 cases [according to the definition of septic shock of American College of Chest Physicians/Society for Critical Care Medicine (ACCP/SCCM)]. CD14(+)/HLA-DR expression ratio was assessed with flow cytometer, and its clinical implication was evaluated by receiver operating characteristic (ROC) curve assay
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|a RESULTS: CD14(+)/HLA-DR expression ratio in infection group [(29.6+/-7.2)%] and septic shock group [(16.3+/-10.5)%] were significantly lower than that in non-infection group [(62.3+/-18.3)%, both P<0.01], but no significant difference of CD14(+)/HLA-DR expression ratio was found between infection group and septic shock group (P=0.128). Total area under ROC curve of CD14(+)/HLA-DR expression ratio for the infection was 0.965, its sensitivity and specificity at 36.35% cut off were 100.0% and 93.6%, respectively. Total area under ROC curve of CD14(+)/HLA-DR expression ratio to predict septic shock was 0.968, its sensitivity and specificity at 31.97% cut off were 100.0% and 87.7%, respectively. Comparing the change of CD14(+)/HLA-DR expression, it was lower in the infection group and septic shock group (P<0.05 and P<0.01), and the expression rate was lowest during period of serious infection in the two groups [infection group: (29.6+/-7.2)%, septic shock group: (16.3+/-0.5)%, all P<0.01]
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|a CONCLUSION: For the patients with possible infection after liver transplantation, sequential assessment of CD14(+)/HLA-DR expression ratio would be a good marker for the judgment of patient's conditions and outcome. CD14(+)/HLA-DR expression ratio below 36.35% could be used as the prewarning value for the diagnosis of postoperative infection, and 31.97% could be used as the critical value for the diagnosis of septic shock
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|a Journal Article
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a HLA-DR Antigens
|2 NLM
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| 650 |
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7 |
|a Lipopolysaccharide Receptors
|2 NLM
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| 700 |
1 |
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|a Guo, Zhen-Hui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Su, Lei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Meng, Fan-Su
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Zhi-Feng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Qiu, Jun-Ming
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Huo, Feng
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
|d 1998
|g 22(2010), 1 vom: 22. Jan., Seite 20-3
|w (DE-627)NLM098227793
|x 1003-0603
|7 nnns
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| 773 |
1 |
8 |
|g volume:22
|g year:2010
|g number:1
|g day:22
|g month:01
|g pages:20-3
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 22
|j 2010
|e 1
|b 22
|c 01
|h 20-3
|