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231223s2009 xx ||||| 00| ||chi c |
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|a (NLM)20078991
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a chi
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| 100 |
1 |
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|a Ru, Jin-li
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Role of DNA-associated autoantibodies to cell membrane in the diagnosis of juvenile systemic lupus erythematosus
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| 264 |
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1 |
|c 2009
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 11.01.2011
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| 500 |
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|a Date Revised 07.06.2016
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a OBJECTIVE: To establish a method of indirect immunofluorescence (IIF) to measure DNA (mDNA)-associated autoantibodies to cell membrane, and to evaluate diagnostic value of the anti-mDNA antibodies in patients with juvenile systemic lupus erythematosus (SLE) in comparison with anti-dsDNA antibody
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| 520 |
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|a METHODS: Forty-four children with SLE were enrolled in this study. As a control group, 30 children with other rheumatic diseases were also enrolled. Anti-mDNA and anti-dsDNA antibodies were measured by IIF. Anti-smooth muscle (Sm) antibodies were measured by immuno-double diffusion (ID) and IIF
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| 520 |
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|a RESULTS: Out of 44 juvenile SLE patients, 34 (77.27%) were seropositive for anti-mDNA, which was significantly higher than that of patients with other rheumatic diseases (20.00%, P<0.05). The sensitivity and specificity of anti-mDNA for juvenile SLE diagnosis were 77.27% and 80.00%, respectively. The positive predictive value and negative predictive value were 85.00% and 70.59%, respectively. The positive rate of anti-mDNA in SLE lacking of anti-dsDNA and anti-Sm antibodies were 68.00% (17/25) and 79.49% (31/39), respectively
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| 520 |
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|a CONCLUSION: The detection of anti-mDNA antibodies is useful for diagnosis of juvenile SLE, especially in patients who are negative for anti-dsDNA antibodies and anti-Sm antibodies
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| 650 |
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|a English Abstract
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| 650 |
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4 |
|a Journal Article
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| 650 |
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|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Antibodies, Antinuclear
|2 NLM
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| 700 |
1 |
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|a Wei, Hua
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lü, Zhi-qin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhao, Chun-yang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Xiao-feng
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Zhonghua er ke za zhi = Chinese journal of pediatrics
|d 1960
|g 47(2009), 11 vom: 18. Nov., Seite 820-3
|w (DE-627)NLM136249191
|x 0578-1310
|7 nnns
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| 773 |
1 |
8 |
|g volume:47
|g year:2009
|g number:11
|g day:18
|g month:11
|g pages:820-3
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|d 47
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