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231223s2010 xx |||||o 00| ||eng c |
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|a 10.1021/la903867a
|2 doi
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|a pubmed24n0646.xml
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|a (NLM)20000430
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Pashkovskaya, Alina
|e verfasserin
|4 aut
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| 245 |
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|a Light-triggered liposomal release
|b membrane permeabilization by photodynamic action
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|c 2010
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 01.07.2010
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|a Date Revised 15.11.2012
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|a published: Print
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|a Citation Status MEDLINE
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|a Photosensitized damage to liposome membranes was studied by using different dye-leakage assays based on fluorescence dequenching of a series of dyes upon their release from liposomes. Irradiation of liposomes with red light in the presence of a photosensitizer, trisulfonated aluminum phthalocyanine (AlPcS(3)), resulted in the pronounced leakage of carboxyfluorescein, but rather weak leakage of sulforhodamine B and almost negligible leakage of calcein from the corresponding dye-loaded liposomes. The same series of selectivity of liposome leakage was obtained with chlorin e6 that appeared to be more potent than AlPcS(3) in bringing about the photosensitized liposome leakage. Electrically neutral zinc phthalocyanine tetrasubstituted with a glycerol moiety (ZnPcGlyc(4)) was less effective than negatively charged AlPcS(3) in provoking the light-induced liposome permeabilization. On the contrary, both ZnPcGlyc(4) and AlPcS(3) were much more effective than chlorin e6 in sensitizing gramicidin channel inactivation in planar bilayer lipid membranes, thus showing that relative photodynamic efficacy of sensitizers can differ substantially for damaging different membrane targets. The photosensitized liposome permeabilization was apparently associated with oxidation of lipid double bonds by singlet oxygen as evidenced by the mandatory presence of unsaturated lipids in the membrane composition for the photosensitized liposome leakage to occur and the sensitivity of the latter to sodium azide. The fluorescence correlation spectroscopy measurements revealed marked permeability of photodynamically induced pores in liposome membranes for such photosensitizer as AlPcS(3)
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Fluoresceins
|2 NLM
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|a Indoles
|2 NLM
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|a Liposomes
|2 NLM
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|a Organometallic Compounds
|2 NLM
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|a Photosensitizing Agents
|2 NLM
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|a Rhodamines
|2 NLM
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|a lissamine rhodamine B
|2 NLM
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|a 2609-88-3
|2 NLM
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|a 6-carboxyfluorescein
|2 NLM
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|a 3301-79-9
|2 NLM
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|a aluminum phthalocyanine
|2 NLM
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|a 47822-79-7
|2 NLM
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|a fluorexon
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|a V0YM2B16TS
|2 NLM
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1 |
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|a Kotova, Elena
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zorlu, Yunus
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dumoulin, Fabienne
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ahsen, Vefa
|e verfasserin
|4 aut
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|a Agapov, Igor
|e verfasserin
|4 aut
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| 700 |
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|a Antonenko, Yuri
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 26(2010), 8 vom: 20. Apr., Seite 5726-33
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:26
|g year:2010
|g number:8
|g day:20
|g month:04
|g pages:5726-33
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|u http://dx.doi.org/10.1021/la903867a
|3 Volltext
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