The most severe forms of type I autoimmune hepatitis are associated with genetically determined levels of TGF-beta1

Published by Elsevier Inc.

Bibliographische Detailangaben
Veröffentlicht in:	Clinical immunology (Orlando, Fla.). - 1999. - 134(2010), 3 vom: 18. März, Seite 305-12
1. Verfasser:	Paladino, Natalia (VerfasserIn)
Weitere Verfasser:	Flores, Ana Claudia, Fainboim, Hugo, Schroder, Teresa, Cuarterolo, Miriam, Lezama, Carol, Ballerga, Esteban Gonzáles, Levi, Diana, Tanno, Hugo, Costanzo, Gabriel, Arruvito, Lourdes, Fainboim, Leonardo
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2010
Zugriff auf das übergeordnete Werk:	Clinical immunology (Orlando, Fla.)
Schlagworte:	Journal Article Research Support, Non-U.S. Gov't Codon Transforming Growth Factor beta DNA 9007-49-2

Beschreibung
Zusammenfassung:	Published by Elsevier Inc. We previously reported that paediatric (PAH) and adult (AAH) forms of type I autoimmune hepatitis (AH) have different HLA-associations and clinical outcome. In the present study we investigated the role of TGF-beta1 genetic polymorphisms in the different outcome of PAH and AAH. We found a significant increase of "high producer" 25GG genotype in PAH and 10CC in AAH. Low inflammation and low fibrosis in AAH was associated with the increase of codon 10CC (high producer) and codon 25CC (low producer) genotypes. The analysis in AAH of the two positions-haplotypes revealed that combined presence of 25GG and 10CC seems to neutralize the 10CC effect which remained in AAH having the 10CC(+)-25GG(-) haplotype. Altogether these results may explain, at least partially, the different clinical outcome of AAH and PAH
Beschreibung:	Date Completed 18.03.2010 Date Revised 17.02.2010 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-7035
DOI:	10.1016/j.clim.2009.11.004