Selective resistance to different glucocorticoids in severe autoimmune disorders

Selective resistance to different glucocorticoids in severe autoimmune disorders

2009 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 134(2010), 3 vom: 18. März, Seite 313-9
1. Verfasser: Drigo, Ilenia (VerfasserIn)
Weitere Verfasser: Piscianz, Elisa, Valencic, Erica, De Iudicibus, Sara, Tommasini, Alberto, Ventura, Alessandro, Decorti, Giuliana
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2010
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't ATP Binding Cassette Transporter, Subfamily B, Member 1 Formazans Glucocorticoids Multidrug Resistance-Associated Proteins Tetrazolium Salts MTT formazan 23305-68-2 DNA mehr... 9007-49-2 Betamethasone 9842X06Q6M Prednisolone 9PHQ9Y1OLM Methylprednisolone X4W7ZR7023 multidrug resistance-associated protein 1 Y49M64GZ4Q
Beschreibung
Zusammenfassung:2009 Elsevier Inc. All rights reserved.
Resistance to glucocorticoids often occurs in patients with severe inflammatory disorders. Occasionally, this resistance could be overcome by switching to a different glucocorticoid, but the mechanisms of this selectivity are not clear. We studied this condition in three patients with severe inflammatory disorders, who responded satisfactorily to betamethasone, but could not be switched to equipotent doses of methylprednisolone or prednisone. While betamethasone displayed similar activity on lymphocyte proliferation in cells obtained from the three patients and controls, higher concentrations of methylprednisolone were needed to inhibit proliferation in patients' cells. In a competition study, the concentration of methylprednisolone that inhibited 50% of specific [(3)H]dexamethasone binding was increased in patients' lymphocytes. Higher Rhodamine-123 efflux was demonstrated in CD4 T cells from two patients, suggesting that an increased activity of membrane transporters could be responsible for the selective response to different glucocorticoids, even if P-glycoprotein and MRP1 expression was not increased
Beschreibung:Date Completed 18.03.2010
Date Revised 01.12.2018
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2009.11.005