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231223s2010 xx |||||o 00| ||eng c |
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|a 10.1021/la903172j
|2 doi
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|a pubmed25n0644.xml
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Chang, Yung
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Hemocompatible mixed-charge copolymer brushes of pseudozwitterionic surfaces resistant to nonspecific plasma protein fouling
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| 264 |
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|c 2010
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 28.05.2010
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|a Date Revised 23.02.2010
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|a published: Print
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|a Citation Status MEDLINE
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|a In this work, the hemocompatibility of a sulfobetaine-like copolymer brush resulting from a mixed-charge copolymerization of the positively charged 11-mercapto-N,N,N-trimethylammonium chloride (TMA) and negatively charged 11-mercaptoundecylsulfonic acid (SA) was studied. Mixed charge distribution in the prepared poly(TMA-co-SA) copolymer brushes was controlled by the regulation of the reaction rate of the surface-initiated atom transfer radical polymerization (ATRP). The adsorption behavior of plasma proteins on a surface grafted with poly(TMA-co-SA) was measured by a surface plasmon resonance (SPR) sensor. The effects of varying temperature, solution pH, and ionic strength on the antifouling characteristics of the mixed-charge copolymer brushes were systematically evaluated, and the protein-fouling resistance was discussed in detail, especially with respect to the effect of ionic strength on the intra- and intermolecular interactions of the poly(TMA-co-SA) with proteins. The adhesion and activation of blood cells on the poly(TMA-co-SA)-grafted surface in contact with human whole blood was also demonstrated. The results suggest that mixed-charge copolymer brushes of poly(TMA-co-SA), which, like zwitterionic homopolymer brushes, have overall charge neutrality, can be used in similar applications for protein-fouling resistance and have excellent hemocompatibility with human whole blood at physiologic temperatures
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|a Journal Article
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4 |
|a Research Support, Non-U.S. Gov't
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|a Biocompatible Materials
|2 NLM
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|a Blood Proteins
|2 NLM
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| 650 |
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|a Polymers
|2 NLM
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| 650 |
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7 |
|a Quaternary Ammonium Compounds
|2 NLM
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| 650 |
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7 |
|a Sulfhydryl Compounds
|2 NLM
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| 700 |
1 |
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|a Shu, Shih-Hung
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shih, Yu-Ju
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chu, Chih-Wei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ruaan, Ruoh-Chyu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Wen-Yih
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1985
|g 26(2010), 5 vom: 02. März, Seite 3522-30
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnas
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| 773 |
1 |
8 |
|g volume:26
|g year:2010
|g number:5
|g day:02
|g month:03
|g pages:3522-30
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|u http://dx.doi.org/10.1021/la903172j
|3 Volltext
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